نتایج جستجو برای: α agonist
تعداد نتایج: 212440 فیلتر نتایج به سال:
Understanding the response of cells to multiple stimuli is vital for predicting donor specific responses and better understanding the signaling pathways involved. This is of particular importance in platelets because exposure of phosphatidylserine (PS) occurs upon costimulation but not with a single agonist. Here, we describe a multiplexed pairwise agonist scanning-flow cytometry (PAS-FC) metho...
فرض کنید r یک حلقه باشد و r[x] حلقه ی چندجمله ای های روی r باشد ارتباط بین پوچ سازهای حلقه ی rو مجموع پوچ سازهای حلقه ی r[x] را بررسی می کنیم. برای حلقه یr ، همریختی α و -α مشتق δ ، مفهوم حلقه ی( -(α, δسازگار ضعیف را معرفی می کنیم که تعمیم حلقه ی -α صلب و ( -(α, δسازگار است. ابتدا خواص حلقه های (-(α, δ سازگار ضعیف را مشاهده می کنیم و سپس ارتباط میان خواص ا...
Oxidative stress has been implicated in the pathogenesis of various cardiovascular diseases, including ischemic heart disease and heart failure. The peroxisome proliferator-activated receptor gamma (PPARγ) agonist improves insulin sensitivity and limits tissue inflammation and cellular apoptosis, but there are few data on the relationship between the PPARγ agonist, rosiglitazone (RSG), and the ...
The conformational changes in the agonist binding domain of the glycine-binding GluN1 and glutamate-binding GluN2A subunits of the N-methyl D-aspartic acid receptor upon binding agonists of varying efficacy have been investigated by luminescence resonance energy transfer (LRET) measurements. The LRET-based distances indicate a cleft closure conformational change at the GluN1 subunit upon bindin...
Although TLR are often studied on DC because of their ability to bridge innate and adaptive defenses, TLR are also expressed by epithelial cells. Because the majority of cancers are carcinomas, and thus of epithelial origin, we wanted to know whether a carcinoma and DC responded similarly to a TLR agonist. We found the mammary carcinoma 4T1 and CD11c(+) DC both secreted proinflammatory chemokin...
Nociceptin (orphanin FQ) is a 17-residue neuropeptide hormone with roles in both nociception and analgesia. It is an opioid-like peptide that binds to and activates the G-protein-coupled receptor opioid receptor-like-1 (ORL-1, NOP, orphanin FQ receptor, kappa-type 3 opioid receptor) on central and peripheral nervous tissue, without activating classic delta-, kappa-, or mu-opioid receptors or be...
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