Background. Bone grafts are used in the treatment of nonunion of fractures, bone tumors and in arthroplasty. Tissues preserved by lyophilization or deep freezing are used as implants nowadays. Lyophilized grafts are utilized in the therapy of birth defects and bone benign tumors, while deep-frozen ones are applied in orthopedics. The aim of the study was to compare the pyrolytic pattern, as an ...

In an endeavor to find a novel series of antihyperglycemic agents, new benzimidazole and pyrimidine derivatives were successfully synthesized efficiently in high yield with high purity, starting from amino acids in the presence of phosphorus oxychloride (POCl3). The synthesized compounds were identified by 1H-NMR, 13C-NMR, FT-IR spectroscopic techniques and elemental analysis. All products were...

Two-step one-pot transformation of primary halides into corresponding nitriles is successfully achieved. Nucleophilic substitution of primary halides with sodium azide and subsequent palladium-catalyzed hydrogen transfer proceeds smoothly in the presence of sterically bulky ligand dicyclohexyl(2',4',6'-triisopropylbiphenyl-2-yl)phosphine (XPhos) in acetone to produce nitriles in satisfactory to...

A helical catalyst that is constructed from α- and δ-amino acids: In their Research Article (e202305326), Alexander J. A. Cobb et al. present a foldamer helix whereby the catalytic functionalities are positioned in such way they can be exploited for bifunctional catalysis. The stability of modularity system (represented by jigsaw pieces) means different α-amino acids used whilst maintaining sam...

Abstract The hydration of nitriles is an important transformation because the resulting primary amides present a huge number applications in synthetic organic chemistry, as well industrial and pharmaceutical interest. Metallic compounds (complexes, oxides, nanoparticles) are known to catalyze by activating nitrile substrate, water molecule, or both partners, upon coordination. In this Minirevie...

Kinetically unstable isocyanides as vinyl, allenyl and propargyl react in Passerini Ugi reactions faster than they decompose lead to functionalized α-acyloxy amides α-amino amides, respectively, which can subsequently be used involving the unsaturated substituent.

Aryl-keto-containing α-amino acids are of great importance in organic chemistry and biochemistry. They are valuable intermediates for the construction of hydroxyl α-amino acids, nonproteinogenic α-amino acids, as well as other biofunctional components. Friedel-Crafts acylation is an effective method to prepare aryl-keto derivatives. In this review, we summarize the preparation of aryl-keto cont...