A supramolecular platform based on self-assembled monolayers (SAMs) has been implemented in a microfluidic device. The system has been applied for the sensing of two different analyte types: biologically relevant phosphate anions and aromatic carboxylic acids, which are important for anthrax detection. A Eu(III)-EDTA complex was bound to β-cyclodextrin monolayers via orthogonal supramolecular h...

A new series of oxovanadium (IV) tetraazamacrocyclic complexes type [VO(mac)]SO4, have been synthesized via in situ reaction 1,8-diaminonaphthalene and substituted β-diketones (1-phenyl-3-(phenyl/4-chlorophenyl/4-hydroxyphenyl/4- methoxyphenyl/4-nitrophenyl)-diketone) the presence oxovanadium(IV) sulphate methanol. Attempts to synthesize corresponding metal free macrocyclic ligands did not prov...

Genetically encoded macrocyclic peptide libraries with unnatural pharmacophores are valuable sources for the discovery of ligands many targets interest. Traditionally, generation such employs “early stage” incorporation building blocks into chemically or translationally produced macrocycles. Here, we describe a divergent late-stage approach to starting from readily available material: genetical...

A novel bis-β-diketone ligand, 4,4'-bis(4,4,4-trifluoro-1,3-dioxobutyl)(phenoxy)-1,1'-binaphthalene (BTPB), is designed for synthesis of a white light emissive lanthanide complex. The ligand bears two benzoyl β-diketonate sites linked by a 1,1'-binaphthoxy spacer. Reaction of the doubly negatively charged bis-bidentate ligand with lanthanide ions forms triple-stranded dinuclear complexes Sm2(BT...

Genistein, daidzein, glycitein and quercetin are flavonoids present in soybean and other vegetables in high amounts. These flavonoids can be metabolically converted to more active forms, which may react with guanine in the DNA to form complexes and can lead to DNA depurination. We assumed two ultimate carcinogen forms of each of these flavonoids, diol epoxide form and diketone form. Density fun...