One of the methods to enhance bio-accessibility of drugs like Acridone and its oxime is toform inclusion complexes with β-cyclodextrin. The formation of such complexes has beenconfirmed by changes in spectral characteristics and melting point data. The aqueous phasesolubility studies reveal 1:1 stoichiometry between the compound and, β-cyclodextrin. The studyof thermodynamic parameters like ΔG,...

one of the methods to enhance bio-accessibility of drugs like acridone and its oxime is toform inclusion complexes with β-cyclodextrin. the formation of such complexes has beenconfirmed by changes in spectral characteristics and melting point data. the aqueous phasesolubility studies reveal 1:1 stoichiometry between the compound and, β-cyclodextrin. the studyof thermodynamic parameters like δg,...

Childhood malaria caused by Plasmodium falciparum is often characterized by severe anemia at low parasite burdens; the mechanism(s) responsible for this pathology remain to be defined. We have reported, based on clinical observations and in vitro models, that complement control proteins on erythrocytes such as CR1, the immune adherence receptor specific for C3b, may be reduced in childhood mala...

During the past few years considerable interest has been shown in the hemoglobin content of chicken blood, especially in the relation of diet and egg production to changes in this blood constituent. The few hemoglobin values which have been reported for normal chickens of the same breed and age show differences rather large in extent. Holmes and coworkers (1) have discussed recently the variati...

A series of novel Zn(II) complexes [Zn2(nap)4] (1), [Zn(nap)21,10-phen](2), [Zn(nap)22,9-dmphen] (3), [Zn(nap)2(2-ampy)2] (4), [Zn(nap)2(imid)2] (5), [Zn(nap)2(1,2-dmimid)2] (6) (nap = naproxen, 1,10-phen = 1,10-phenanthroline, 2,9-dmphen = 2,9-dimethyl-1,10-phenanthroline, 2-ampy = 2-aminopyridine, imid = imidazole, 1,2-dmimid = 1,2-dimethyl imidazole) were synthesized and characterized using ...

Continuous assay of the soluble and inducible tryptophan pyrrolase (L-tryptophan : Hz02 oxidoreductase, EC 1.11.1.4) by direct spectrophotometry in the particle-free supcrnatant fraction of liver (1) would be a desirable alternative to t,he usual assay in whole liver homogenates (2) for studies of the adaptive variations of the concentration of this enzyme, but it is uncertain whether the total...

At four positions within the native globin molecule heme may combine to give a protein, capable of reversible combination with oxygen (1, 2) and identical with hemoglobin (3, 4). As many as thirty hemes may react with denatured globin, but the product cannot be reversibly oxygenated. Many other nitrogen-containing compounds combine with reduced hematin to form hemochromogens, but none of these ...