Fucoxanthinol (FxOH), the main metabolite of marine carotenoid fucoxanthin, exerts anti-cancer effects. However, fragmentary information is available on growth-inhibiting effects FxOH breast cancer (BC). We investigated human BC cells (MCF-7 and MDA-MB-231 cells), underlying mechanisms, differently from previous studies, by using comprehensive transcriptome analysis. The molecular mechanisms we...

The key principle of gene delivery to articulations by direct intra-articular injection is to release complementary DNA(cDNA)-encoding medical products that will lead to maintained, endogenous production of the gene products withinthe articulation. In fact, this has been accomplished for both in vivo and ex vivo gene delivery, using several vectors,genes, and cells in some animal models. Some c...

Transforming growth factor (TGF)-β and bone morphogenetic protein (BMP) induce a cartilage-specific extracellular matrix (ECM) gene, aggrecan, in a chondrogenic cell line, ATDC5. The results of our recent study show that TGF-β1, but not BMP-4, strongly induces an ECM gene, fibronectin, during chondrogenesis. However, the role of fibronectin in chondrogenesis is unclear. In the current study, ou...

TGF-β1 is a cytokine producing extracellular matrix. We evaluated TGF-β1 gene polymorphism at codon 10 and the risk of HCC in Egyptian patients with HCV infection. TGF-β1 gene polymorphism was performed by the amplification refractory mutation system (ARMS-PCR). A significant difference in allelic frequency between control and HCV patients (p = 0.05). Logistic regression showed that the load of...

Transforming growth factor beta (TGF-β) is a multifunctional protein that induces gene expression of cartilage-specific molecules, but its exact role in the process of chondrogenesis is unclear. Because recent studies suggest that TGF-β can facilitate chondrogenic precursor cells differentiating into chondrocytes, we sought to determine whether TGF-β prevents denervation-induced reduction of en...

The aim of this study is to investigate the effect scutellarein on proliferation neuroblastoma cells and underlying mechanism. Six cell lines were used with drug intervention. Cell Counting Kit-8 was select best, namely, SH-SY5Y, then its IC50 value determined. To further mechanism scutellarin affecting SH-SY5Y proliferation, quantitative real-time polymerase chain reaction (qRT-PCR) detect exp...

Several studies have demonstrated that cytokine-mediated noncytopathic suppression of hepatitis B virus (HBV) replication may provide an alternative therapeutic strategy for the treatment of chronic hepatitis B infection. In our previous study, we showed that transforming growth factor-beta1 (TGF-β1) could effectively suppress HBV replication at physiological concentrations. Here, we provide mo...

Introduction: Visceral leishmaniasis (VL) or Kala-azar is a parasitic disease caused by a protozoan of Leishmania genus and in Iran by Leishmania infantum. Cytokines have a major role in determining progression and severity of clinical manifestations in VL. The role of TGF-β1 in VL has been recognized since 1992. We investigated polymorphism in the TGF-β1 gene, which is a cytokine known to have...

Cell adhesion controls various embryonic morphogenetic processes, including the development of the enteric nervous system (ENS). Ablation of β1-integrin (β1-/-) expression in enteric neural crest cells (ENCC) in mice leads to major alterations in the ENS structure caused by reduced migration and increased aggregation properties of ENCC during gut colonization, which gives rise to a Hirschsprung...

Transforming growth factor-β1 (TGF-β1) is an important fibrogenic and immunomodulatory cytokine participating in the pathogenesis of a number of illnesses related to the growth, differentiation and migration of cells. It also plays a key role in inflammation, atherosclerosis, vascular inflammation and asthma. The aim of the present study was to evaluate the association between the expression of...