Mutant p53 (mtp53) gain of function (GOF) contributes to various aspects of tumor progression including cancer stem cell (CSC) property acquisition. A key factor of GOF is stabilization and accumulation of mtp53. However, the precise molecular mechanism of the mtp53 oncogenic activity remains unclear. Here, we show that ribophorin II (RPN2) regulates CSC properties through the stabilization of ...

This document reports a simple and effective method to determine global camera motion using raw MPEG-1 motion vectors information obtained straight from the real MPEG-1 streams such as that of the new HITACHI MP-EG1A digital camcorder. The simple approach we have experimented with robustly fits a global affine optic flow model to the motion vectors. Other more robust methods are also proposed. ...

Rozo and Gronvall, in “The Reemergent 1977 H1N1 Strain and the Gain-of-Function Debate” (1), confirmed the laboratory origin of the 1977 influenza pandemic and judged it was unintentional, but they concluded that its “relevance to GoF research is greatly diminished if the 1977 epidemic was the result of a vaccine trial or vaccine development gone awry; these are both more plausible explanations...

Abstract We propose a spatiotemporal point process model that enhances the classical Epidemic-Type Aftershock Sequence (ETAS) model. This is achieved with introduction of renewal main-shock arrival and we call this extension ETAS (RETAS) modification similar in spirit to Hawkes (RHawkes) but conditional intensity supports spatial component. It empowers reset upon main-shocks. allows for heavier...

The research has measured the landslide using a displacement sensor based on Glass Optical Fiber (GOF) and Time Domain Reflectometer (OTDR). manufacture process consists of various materials, structures, configurations, diameters, directions. is made GOF with single-mode structure single mode-multimode-Singlemode (SMS) structure. Each system given variety namely gamma, bowknot, three loops conf...

Chronic mucocutaneous candidiasis (CMC) is characterized by a chronic or recurrent non invasive infection, mainly due to Candida albicans , in skin, nails, and mucous membranes, associated some cases with autoimmune manifestations. The key immune defect disruption of the action cytokine IL-17, whose most common genetic etiology STAT1 gene gain-of function (GOF) mutations. initial appropriate tr...