An efficient enantioselective synthesis of the chiral polycyclic cholesteryl ester transfer protein (CETP) inhibitor 1 has been developed. The synthesis was rendered practical for large scale via the development of a modified Hantzsch-type reaction to prepare the sterically hindered pyridine ring, enantioselective hydrogenation of hindered ketone 6 utilizing novel BIBOP-amino-pyridine derived R...

This review summarizes the new carbon-carbon bond construction methods based on the radical reaction of imine derivatives. The intermolecular carbon radical addition to oxime ethers proceeded smoothly in the presence of BF3.OEt2. A high degree of stereocontrol in the reaction of oxime ethers was achieved to give amino acid derivatives with excellent diastereoselectivities. The radical reaction ...

A divergent strategy for the synthesis of the tricyclic 6,7-diaryltetrahydro-6H-benzo[c]chromene core was successfully developed. The 2,3-trans, 2,4-cis trisubstituted chroman moiety was formed via highly efficient and stereoselective Pt(IV)-catalyzed cycloaddition reactions of the corresponding quinone methides with chalcones. Subsequent steps provided the common diene alcohol, which underwent...

Nano-silica supported boron trifluoride (BF3.SiO2) is an efficient, reusable and eco-friendly catalyst for chemoselective thioacetalization of aldehydes and ketones. So, this catalyst was applied for transthioacetalization of acetals and acylals into their corresponding 1,3-dithiolanes or 1,3-dithianes  in good to excellent yields. The reactions were carried out at room temperature under solven...

The Knoevenagel condensation of aromatic aldehydes with barbituric acid, dimedone and malononitrile occurred in the presence of BF3/nano-γ-Al2O3 at room temperature in ethanol. This catalyst is characterized by powder X-ray diffraction (XRD), fourier transform infrared spectroscopy (FT-IR), thermal gravimetric analysis (TGA), field emission scanning electron microscopy (FESEM) and energy-disper...