Background. Preventive vaccination is a vitally important strategic aspect of protection the population against severe effects influenza epidemics. The priority attention given to development effective tetravalent vaccines containing antigens two A lineages (H1N1, H3N2) and B (Victoria Yamagata) in combination with immunoadjuvants.The aim work was conduct preclinical study immunogenicity protec...

BACKGROUND During the 2009 H1N1 pandemic, pregnant women were prioritized to receive the unadjuvanted or MF59®-adjuvanted pandemic A (H1N1) 2009 monovalent vaccines ("2009 H1N1 vaccines") in Taiwan regardless of stage of pregnancy. Monitoring adverse events following 2009 H1N1 vaccination in pregnant women was a priority for the mass immunization campaign beginning November 2009. METHODS/FIND...

Em abril de 2009, surgia um surto da doença causada pelo então novo vírus influenza A(H1N1), que teve rápido poder disseminação. Inicialmente a ficou conhecida como “gripe suína”, por conta do evento genético ocasionou emergência subtipo pandêmico resultado recombinação genética suíno, aviário e humano, tendo elevado potencial disseminação entre humanos. Deste modo, o presente estudo pautou-se ...

BACKGROUND The innate immune system is the first line of defense against viruses by inducing expression of cytokines and chemokines. Many pandemic influenza H1N1 virus [P(H1N1)] infected severe cases occur in young adults under 18 years old who were rarely seriously affected by seasonal influenza. Results regarding host cytokine profiles of P(H1N1) are ambivalent. In the present study we invest...

CONTEXT The clinical characteristics of pandemic 2009 influenza A(H1N1) infections have not been compared directly with illnesses caused by other influenza A strains. OBJECTIVE To compare clinical features and outcomes for 2009 H1N1, seasonal H1N1, and H3N2 influenza in a population-based cohort. DESIGN, SETTING, AND PARTICIPANTS Active surveillance with 30-day follow-up for influenza cases...

Persons with high-risk conditions such as asthma were a target group for H1N1 vaccine recommendations. We conducted a mailed survey of a national sample of pulmonologists to understand their participation in the 2009-2010 H1N1 vaccine campaign. The response rate was 59%. The majority of pulmonologists strongly recommended H1N1 vaccine for children (73%) and adults aged 25-64 years (51%). Only 6...

introduction: this study aimed to evaluate the clinical profile and outcomes of adult patients screened and diagnosed with h1n1 influenza infection at a tertiary care hospital in india. materials and methods: this retrospective  study was conducted on all adult patients suspected of h1n1 influenza admitted at a teaching hospital during the epidemic period of january-march 2015. patients were sc...

Pandemic 2009 H1N1 influenza A virus (2009 H1N1) differs from H1N1 strains that circulated in the past 50 years, but resembles the A/New Jersey/1976 H1N1 strain used in the 1976 swine influenza vaccine. We investigated whether sera from persons immunized with the 1976 swine influenza or recent seasonal influenza vaccines, or both, neutralize 2009 H1N1. Using retroviral pseudovirions bearing hem...