نتایج جستجو برای: اصل 139
تعداد نتایج: 27989 فیلتر نتایج به سال:
OBJECTIVE This phase I clinical study (NCT01415297) evaluated the safety, tolerability, maximum-tolerated dose (MTD), pharmacokinetics and pharmacodynamics of IT-139 (formerly NKP-1339) monotherapy in patients with advanced solid tumours. IT-139, sodium trans-(tetrachlorobis(1H-indazole)ruthenate(III)), is a novel small molecule that suppresses the stress induction of GRP78 in tumour cells. GRP...
Escherichia coli strains belonging to O-serogroup 138 and 139 are important as disease agents in pigs causing post-weaning diarrhea and edema disease. Several types of shiga toxin-producing O 138 and O 139 strains were isolated from diarrheic humans and from cattle and food of bovine origin. Serotyping is the current method for detection of O 138 and O 139 strains but its applicability can be l...
In the light of current flooding events in Bulgaria, Serbia and Romania [1], staff at the European Centre for Disease Prevention and Control (ECDC) have undertaken some preliminary review of the adverse health effects of such natural disasters. Flood events are the most frequently occurring natural disasters worldwide, and may increase in the future as a result of climate change [2]. Adverse ef...
Oral cancer threats people's life and health seriously. Traditional treatment (surgery, radiotherapy, chemotherapy and traditional Chinese medicine treatment) is lack of pertinence that affects curative effect and prognosis. Therefore, it is necessary to explore the specific targets for oral cancer treatment. MiRNA-139 was transfected into oral cancer Tca8113 cells. Methyl thiazolyl tetrazolium...
The structures of the β- and t-LaOF phases have been refined from XRPD patterns. For both phases, (19)F and (139)La solid-state NMR spectra recorded at high magnetic fields show the presence of a single F and a single La local environment, indicating a full anionic ordering in these oxyfluoride compounds. DFT calculations of the (19)F and (139)La chemical shielding tensors and of the (139)La EF...
Metastasis is a complex, multistep process involved in the progression of cancer from a localized primary tissue to distant sites, often characteristic of the more aggressive forms of this disease. Despite being studied in great detail in recent years, the mechanisms that govern this process remain poorly understood. In this study, we identify a novel role for miR-139-5p in the inhibition of br...
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