The stereoselective disposition of carbenicillin epimers was studied in healthy human volunteers. There was a difference between the two epimers in the extent of plasma protein binding in vitro, with the unbound fraction of the R epimer being greater than that of the S epimer. Renal clearance (CLR) of each epimer was greater than the glomerular filtration rate, suggesting renal tubular secretio...

Clustered linear regression (CLR) is a new machine learning algorithm that improves the accuracy of classical linear regression by partitioning training space into subspaces. CLR makes some assumptions about the domain and the data set. Firstly, target value is assumed to be a function of feature values. Second assumption is that there are some linear approximations for this function in each su...

Three separate controlled, two-period studies with healthy volunteers assessed the pharmacokinetic interactions between tipranavir-ritonavir (TPV/r) in a 500/200-mg dose and 500 mg of clarithromycin (CLR), 100 mg of fluconazole (FCZ), or 150 mg of rifabutin (RFB). The CLR study was conducted with 24 subjects. The geometric mean ratios (GMR) and 90% confidence intervals (90% CI; given in parenth...

Inoculating plants with arbuscular mycorrhizal fungi (AMF) protects host against biotic stressors such as diseases. Therefore, the objective of this study was to evaluate influence in biological control coffee leaf rust (CLR) infections. The research involved two varieties (Caturra and Pache) three inocula AMF: Moyobamba (Acaulospora mellea, Acaulospora sp.1, Glomus geosporum, sp.2), El Dorado ...

Simulation-Based Study K. E. Hill, R. A. Dave, M. E. Morris University at Buffalo Purpose Renal clearance (CLR) is an important pathway of elimination for drugs with poor metabolism and biliary clearance. The objectives of this study were to evaluate the effects of renal impairment (RI) on: (1) pharmacokinetics (PK) of a drug that undergoes renal transporter-mediated active reabsorption, (2) tr...

This study aimed to design a hyaluronic acid-based targeted, mucoadhesive and mucopenetrating drug delivery system encapsulating clarithromycin that would improve the residence time at H. pylori infection site. Clarithromycin-loaded thiolated acid-co-oleic acid (CLR-thHA-co-OA), clarithromycin-loaded ureido-conjugated (CLR-Ur-thHA-co-OA), papain-modified acid-co- oleic (CLR-PAP-Ur-thHA-co-OA) n...

We give a short proof of the Cwikel–Lieb–Rozenblum (CLR) bound on the number of negative eigenvalues of Schrödinger operators. The argument, which is based on work of Rumin, leads to remarkably good constants and applies to the case of operator-valued potentials as well. Moreover, we obtain the general form of Cwikel’s estimate about the singular values of operators of the form f(X)g(−i∇).

Chemical looping reforming (CLR) is an emerging hydrogen/syngas production technology, integrated with CO 2 capture.

Coffee is an important plantation crop cultivated worldwide and used as stimulating drink. leaf rust (CLR) disease one of the devastating affecting foliage Coffee, limiting production worldwide. It caused by obligate parasite Hemileia vastatrix, which reduce photosynthetic area in turn results heavy defoliation die-back branches. In India CLR management accomplished with contact fungicide spray...