intracerebroventricular (icv) injection of streptozotocin (stz) in rats is followed by long-term and progressive deficits in learning, memory, and cognitive performance which is somewhat similar to sporadic alzheimer’s disease (sad). epidemiological studies suggest that non-steroidal anti-inflammatory drugs (nsaids) could delay or slow the clinical expression of sad. therefore, the beneficial e...

INTRODUCTION Dimethyl sulfoxide (DMSO) is a chemical often used as a solvent for water-insoluble drugs. In this study, we evaluated the effect of intracerebroventricular (ICV) administration of DMSO on neural response characteristics (in 1200-1500 μm depth) of the rat barrel cortex. METHODS DMSO solution was prepared in 10% v/v concentration and injected into the lateral ventricle of rats. Ne...

Arva S., Zendehdel M., EbrahimNezhad Y., Ghiasi Ghalehkandi J., Hassanpour S., Aghdam Shahryar H. (2017): Effect of opioid receptors agonists on feeding behaviour using different diets in ad libitum fed neonatal chicken. Czech J. Anim. Sci., 62, 98–109. Despite progress in studying the role of opioids in reward, the effect of opioid receptors on feeding behaviour in ad libitum fed meat-type chi...

The effect of intracerebroventricular (ICV) antileptin antibody on the onset of puberty in the female rat and the relationship between serum leptin, luteinizing hormone (LH), and body weight were investigated. Antileptin antibody (group A) was infused ICV from days 23-36 in prepubertal female rats whereas the control (group B) received ICV goat immunoglobulin G (IgG). In the antileptin group, m...

A clock synchronization service ensures that spatially dispersed and heterogeneous processors in a distributed system share a common notion of time. In order to behave as a single, unified computing resource, distributed systems have need for a fault-tolerant, clock synchronization service. One approach employs the interactive convergence (ICV) method, which is both fully distributed and inhere...

OBJECTIVE(S) The aim of study was to investigate the antinociceptive effect of intracerebroventricular (ICV) microinjection of Origanum vulgare (ORG) extract and possible involvement of opioid receptors. MATERIALS AND METHODS Cannula was inserted into left ventricle of male rats. Five days after surgery Tail Flick Latency (TFL) was measured after ICV microinjection of, ORG (1, 3 and 6 µg / ra...

We investigated the effects of intracerebroventricular (ICV) injection of orexin-A on plasma corticosterone (CORT) concentration and brain monoamine metabolism to clarify the mechanism by which ICV orexin-A induced arousal in chicks. In Experiment 1, plasma CORT concentrations were measured as an indicator of hypothalamic-pituitary-adrenal (HPA) axis activity. There was no significant differenc...

The present study was designed to investigate the role of central adrenoceptors in the hypotensive effect of intracerebroventricular (ICV) injection of norepinephrine (NE) in conscious rabbits. Experiments were carried out on 19 adult rabbits (oryctolagus cuniculus) of either sex. A dose-dependent hypotensive response to ICV injection of NE was observed with no significant change in heart rate....