The purpose of this paper is to review the possible role of polypharmacy in causing dry eye disease (DED), reflecting the complex interactions and complications associated with the use of multiple systemic and topical ocular medications. The pharmacological, physiological, anatomical, and histological mechanisms causing dry mouth differ little from those causing dry eye. Oral polypharmacy is th...

 Abstract—This paper is a reply to the comments on " Integer SEC-DED codes for low power communications " .

Dry eyes, also known as dry eye disease (DED), syndrome, and keratoconjunctivitis sicca (KCS), are among the most common reasons people visit an doctor. Other names for eyes include: (KCS). Environmental factors that may have a role include, but not limited to, exposure to irritants such chemical vapors, cigarette smoke, pollution, or low humidity. Smoking cigarettes, which is modifiable risk f...

The many internal and external factors that contribute to the pathophysiology of dry eye disease (DED) create a difficult milieu for its study and complicate its clinical diagnosis and treatment. The controlled adverse environment (CAE®) model has been developed to minimize the variability that arises from exogenous factors and to exacerbate the signs and symptoms of DED by stressing the ocular...

Clustering data streams is one of the prominent tasks discovering hidden patterns in streams. It refers to process clustering newly arrived into continuously and dynamically changing segmentation patterns. This article presents a stream mining algorithm cluster with focusing on its evolution concept drift. Even though drift expected be present streams, explicit detection rarely done algorithms....

A new topical ophthalmic medication, lifitegrast 5%, was recently approved by the US Food and Drug Administration for use in dry eye patients. Lifitegrast is an integrin antagonist that decreases inflammation on the ocular surface, thereby improving dry eye disease (DED). Through a series of prospective, multicenter, randomized, masked, placebo-controlled studies in >2,000 patients total, lifit...

Dry eye disease (DED) is a major public health problem worldwide that seriously impairs the quality of life, reduces work productivity, and poses significant economic burden. In DED, tear film instability or hyperosmolarity activates self-perpetuating vicious cycle may aggravate ocular surface inflammation damage. Thus, treatment approaches should focus on interrupting this ameliorating inflamm...

Abstract Fe-based amorphous coatings are typically known for their high hardness and wear resistance often applied using thermal spraying techniques. When cladding these materials, laser directed energy deposition (DED), it becomes possible to vary the cooling rate create unique microstructures. Herein, is demonstrated that a common FeCrMoBC coating alloy, its hardness, can be fabricated into v...

Dry eye disease (DED) is a common chronic ophthalmic disorder, and there no effective treatment to cure it. It urgent find new antidry compounds. Here, the effects underlying mechanisms of tilapia skin peptides (TSP) on DED were investigated. In vitro, human corneal epithelial cells (HCECs) cultured in hypertonic medium containing TSP for 12 h. The MTT assay, calcein-AM/PI staining, reactive ox...