INTRODUCTION .................................... 284 Nonspecific Resistance to Infection .......................................... 284 Specific Resistance to Infection .............................................. 285 CELLS INVOLVED IN HUMORAL ANTIBODY PRODUCTION ............. 285 CELLS INVOLVED IN CELL-MEDIATED IMMUNITY ................. 287 HUMORAL ANTIBODIES IN RESISTANCE TO BACTERIAL INF...

Gem is a small GTP-binding protein that has a ras-like core and extended chains at each terminus. The primary structure of Gem and other RGK family members (Rad, Rem, and Rem2) predicts a GTPase deficiency, leading to the question of how Gem functional activity is regulated. Two functions for Gem have been demonstrated, including inhibition of voltage-gated calcium channel activity and inhibiti...

. clicking here colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others . here following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles (this information is current as of August 2, 2010 ): The following resources related to this article are available online at www....

Human mitochondrial NAD kinase is a crucial enzyme responsible for the synthesis of mitochondrial NADP(+). Despite its significance, little is known about the regulation of this enzyme in the mitochondria. Several putative and known phosphorylation sites within the protein have been found using phosphoproteomics, and here, we examined the effect of phosphomimetic mutations at six of these sites...

We have demonstrated previously that cisplatin (DDP) and tamoxifen (TAM) act synergistically to kill human melanoma T-289 cells, and that the observed synergy is lost in the 3-fold TAM-resistant subline, 289/TAM6. We have identified the intracellular antiestrogen-binding sites (AEBSs), defined by their ability to bind antiestrogens while having no affinity for estrogen, as a possible mediator o...

Abstract Introduction Significant blood loss is associated with a delayed postoperative recovery in joint arthroplasty. Emerging evidence suggests robotic-assisted knee arthroplasty reduces soft-tissue trauma, length of stay, and can facilitate faster recovery. This study compares the total patients undergoing compared to conventional methods. Method Patients (TKA) or unicomparmental (UKA) were...