Silymarin (SL), a mixture of flavonolignans mainly including silybin A and B, isosilybin A and B, silidianin, and silychristine from the seeds of Silybum marianum L., has been widely used to treat acute and chronic viral hepatitis, toxin/drug-induced hepatitis, cirrhosis, alcoholic fatty liver diseases and other ailments because of its excellent hepatoprotective effect. Silybin is the most acti...

Silymarin is a standardized extract from the dried seeds of the milk thistle (Silybum marianum L. Gaertn.) clinically used as an antihepatotoxic agent. The aim of this study was to investigate the antibacterial and antifungal activity of silymarin and its major constituent (silibinin) against different microbial strains and their modulatory effect on drugs utilized in clinical practice. Silymar...

many aldehydes are important components of natural flavours. they are used in food, cosmetic, and biomedical industries in large amounts. plant cells or microorganisms carry out their production by biotransformation, which is one of the biotechnological methods that allow them to be defined as 'natural'. cell cultures of silybum marianum and peganum harmala have been studied with a vi...

BACKGROUND Silymarin derived from silybum marianum (milk thistle), a flowering member of the daisy family, may benefit liver function in people infected with the hepatitis C virus. The aims of this pilot study were to assess the efficacy and safety of silymarin on serum hepatitis C virus (HCV) RNA, serum aminotransferases (ALT, AST) levels, liver fibrosis and well-being in patients with chronic...

The antifungal activity of ethanol extract of Silybum marianum was investigated invitro against three strains of Rhizoctonia solani at different concentrations (5, 10, 15 and 20%). Bioassay of extract was conducted by poisoned food technique with three replications. The findings showed that strain of R. solani (Eggplant) was susceptible to concentrations of S. marianum more than other strains i...

A comprehensive metabolomic profiling of Silybum marianum (L.) Gaernt cell cultures elicited with yeast extract or methyl jasmonate for the production of silymarin was carried out using one- and two-dimensional nuclear magnetic resonance spectroscopy. With these techniques we were able to detect both temporal quantitative variations in the metabolite pool in yeast extract-elicited cultures and ...