Since the first description of human fragile sites (FS) more than 40 years ago, a variety of substances were reported to induce chromosomal breaks at non-random, breakage-prone regions. According to information available from human genome browsers aphidicolin, an inhibitor of DNA replication induces 77 of 88 known common FS. However, in the literature additional FS are reported, which are also,...

هدف: هدف از انجام این پژوهش مقایسه اثربخشی طرح‌واره‌درمانی و واقعیت‌درمانی بر انعطاف‌پذیری روان‌شناختی خودتنظیمی هیجانی مربیان پیش‌دبستانی شهرستان شهرکرد بود. روش: جامعه آماری کلیة شهرکردبودند که بین آنها تعداد 45 نفر به صورت نمونه‌گیری در دسترس انتخاب گمارش تصادفی 2 گروه آزمایش و1 کنترل (هر کدام 15 نفر) گمارده شدند. ابزار اندازه‌گیری شامل پرسشنامه‌های (بوند همکاران، 2011) هیجانی(مارس، 1983) بو...

Fast-spiking (FS) interneurons in the brain are self-innervated by powerful inhibitory GABAergic autaptic connections. By computational modelling, we investigate how autaptic inhibition regulates the firing response of such interneurons. Our results indicate that autaptic inhibition both boosts the current threshold for action potential generation as well as modulates the input-output gain of F...

Inhibition from fast-spiking (FS) interneurons plays a crucial role in shaping cortical response properties and gating developmental periods of activity-dependent plasticity, yet the expression mechanisms underlying FS inhibitory plasticity remain largely unexplored. In layer 4 of visual cortex (V1), monocular deprivation (MD) induces either depression or potentiation of FS to star pyramidal ne...

The addition of antibiotics to an adhesive haemostat results in an ideal system for the treatment of a localized infectious disease. Fibrin sealant (FS) is a biocompatible, resorbable, adherent haemostat that can deliver antibiotics. Previous use of fibrin to deliver antibiotics resulted in rapid release and limited bioactivity. We have reported previously that poorly soluble antibiotics signif...

The recent Chu et al. (2012) manuscript discusses two key findings regarding feature selection (FS): (1) data driven FS was no better than using whole brain voxel data and (2) a priori biological knowledge was effective to guide FS. Use of FS is highly relevant in neuroimaging-based machine learning, as the number of attributes can greatly exceed the number of exemplars. We strongly endorse the...

A new type of nitric oxide (NO)-releasing material is described that utilizes S-nitrosothiols anchored to tiny fumed silica (FS) particles as the NO donor system. The synthetic procedures suitable for tethering three different thiol species (cysteine, N-acetylcysteine, and N-acetylpenicillamine) to the surface of FS polymer filler particles are detailed. The thiol-derivatized particles are conv...

PURPOSE Transient elastography (Fibroscan(©); (FS)) and acoustic radiation force impulse imaging (ARFI) represent noninvasive, user-friendly and quick methods providing an objective and reproducible measure of liver stiffness. The aim of the study was to evaluate cut-off values and performance of ARFI measurements in children using transient elastography as a reference. METHODS/PATIENTS A tot...

INTRODUCTION Many surgeons use intraoperative frozen-section (FS) biopsy of thyroid nodules to predict malignant disease, but the findings are often not in agreement with those of fine-needle aspiration (FNA) biopsy. Our objective in this study was to assess the value of intraoperative FS biopsy in patients with nodular disease of the thyroid gland. METHODS In this study, 203 patients underwe...

Febrile seizures (FS) are the most common type of convulsive events in infancy and childhood. Genetic and environmental elements have been suggested to contribute to FS. FS can be divided into simple and complex types, the former being benign, whereas it is controversial whether complex FS have an association with the development of temporal lobe epilepsy (TLE) in later life. In the hippocampus...