Mandibuloacral dysplasia (MAD; OMIM 248370) is a rare, genetically and phenotypically heterogeneous, autosomal recessive disorder characterized by skeletal abnormalities including hypoplasia of the mandible and clavicles, acro-osteolysis, cutaneous atrophy and lipodystrophy. A homozygous missense mutation, Arg527His, in the LMNA gene which encodes nuclear lamina proteins lamins A and C has been...

The dissociation behavior of phosphorylated and sulfonated peptide anions was explored using metastable atom-activated dissociation mass spectrometry (MAD-MS) and collision-induced dissociation (CID). A beam of high kinetic energy helium (He) metastable atoms was exposed to isolated phosphorylated and sulfonated peptides in the 3- and 2- charge states. Unlike CID, where phosphate losses are dom...

Gebhardt et al. (2014) presented the Monitoring Activity Data for the Mexican REDD+ program (MAD-MEX), an automatic nation-wide land cover monitoring system for the Mexican REDD+ MRV. Though MAD-MEX represents a valuable first effort toward establishing a national reference emissions level for the implementation of REDD+ in Mexico, in this paper, we argue that this land cover system has importa...

An adjacent vertex distinguishing total coloring of a graph G is a proper total coloring of G such that any pair of adjacent vertices are incident to distinct sets of colors. The minimum number of colors required for an adjacent vertex distinguishing total coloring of G is denoted by χ′′ a(G). Let mad(G) and ∆(G) denote the maximum average degree and the maximum degree of a graph G, respectivel...

Transcriptional repression by Mad-Max heterodimers requires interaction of Mad with the corepressors mSin3A/B. Sin3p, the S. cerevisiae homolog of mSin3, functions in the same pathway as Rpd3p, a protein related to two recently identified mammalian histone deacetylases, HDAC1 and HDAC2. Here, we demonstrate that mSin3A and HDAC1/2 are associated in vivo. HDAC2 binding requires a conserved regio...

The N-CoR/SMRT complex containing mSin3 and histone deacetylase (HDAC) mediates transcriptional repression by nuclear hormone receptors and Mad. The proteins encoded by the ski proto-oncogene family directly bind to N-CoR/SMRT and mSin3A, and forms a complex with HDAC. c-Ski and its related gene product Sno are required for transcriptional repression by Mad and thyroid hormone receptor (TRbeta)...

The study shows that multiaxial deformation (MAD) treatment leads to grain refinement in magnesium alloy WE43. Compared the initial state, MAD-processed exhibited smoother biocorrosion dynamics a fetal bovine serum and complete cell growth medium. Examination by microCT demonstrated retardation of decline volume Hounsfield unit values. An attendant reduction rate accumulation biodegradation pro...

OBJECTIVE This study aims to investigate the demographic, toxicological characteristics of the mad honey intoxication at ages 65 and above, to analyze the electrocardiographic parameters, and to compare with the mad honey intoxication at ages below 65 years. PATIENTS AND METHODS Eighty-two patients, who had been treated and followed-up between June 2013 and November 2014 in the Emergency Serv...