microRNAs, frequently deregulated in human cancer, have been implicated in the progression of hepatocarcinogenesis. Here, we show that microRNA (miR)-137 is significantly down-regulated in hepatocellular carcinoma (HCC). Its decreased expression is associated with vein invasion, incomplete Involucrum, and distant metastasis. Multivariate analysis suggests that miR-137 is an independent indicato...

MicroRNA-137 (miR-137) was reported to be dysregulated in several human cancers. However, the function and mechanism of miR-137 in non-small cell lung cancer (NSCLC) is still unclear. In the current study, we explored the role of miR-137 in NSCLC progression. Using qRT-PCR, our data showed that miR-137 was significantly down-regulated in NSCLC tissues and cell lines. In vitro functional assay, ...

To track the long term bioaccumulation of (137)Cs in marine organisms off the Pacific Northwest coast of Canada, we developed a time dependent bioaccumulation model for (137)Cs in a marine mammalian food web that included fish-eating resident killer whales. The model outcomes show that (137)Cs can be expected to gradually bioaccumulate in the food web over time as demonstrated by the increase o...

Concentration of activity of Cs-137 and its spatial distribution in soils and lichen Hypogymnia physodes were determined in the Gorce Mts. (several hundred km2) in S Poland. The authors distinguished two areas of the Gorce Mts. on the basis of markedly different Cs-137 depositions, whose respective average values are 4.4 and 9.9 kBq/m2 as at 1st July 2005. The average Cs-137 activity concentrat...

BACKGROUND Oxidative stress, inducing cardiomyocyte apoptosis or myocardial ischemia, is the major denominator of many cardiac diseases. In this study, we intended to explore the regulatory function of microRNA-137 (miR-137) in oxidative stress-induced cardiomyocyte apoptosis. MATERIAL AND METHODS Cardiomyocytes were extracted from newborn C57BL/6 mice and cultured in vitro. Apoptosis was ind...

Concentration factors (CF: Bq.kg-1 in wet algae/Bq.kg-1 in filtered seawater) for Cs-137 in Japanese coastal algae, were investigated during 1984-1990. Cs-137/Cs(stable) atom ratios were also examined to clarify the distribution equilibrium of Cs-137 in marine algae and sea water. The CFs in marine algae were within the range of 5.4 approximately 92, and the geometric mean of CF was 28 +/- 2 (s...

Of the natural processes that concentrate dispersed environmental contaminants, landscape fire stands out as having potential to rapidly concentrate contaminants and accelerate their redistribution. This study used rainfall simulation methods to quantify changes in concentration of a widely dispersed environmental contaminant (global fallout 137Cs) in soils and surface water runoff following a ...

Details of the research undertaken in our laboratory can be found at http://www.dstuns.iitm.ac.in/pradeep-research-group.php. A green route to synthesise glutathione protected atomically precise silver clusters by sunlight irradiation of silver thiolates confi ned in gel cavities, and the antibacterial properties of the as-synthesized clusters against gram-negative and gram-positive bacteria. A...