Abstract The progression and metastatic capacity of solid tumors are strongly influenced by immune cells in the tumor microenvironment. In non–small cell lung cancer (NSCLC), accumulation anti-inflammatory tumor-associated macrophages (TAM) is associated with worse clinical outcome resistance to therapy. Here we investigated landscape NSCLC presence protumoral TAMs expressing macrophage recepto...

Background and objectives:Scrophularia variegata M. Beib. (Scrophulariaceae) is a medicinal plant, used for various inflammatory diseases in Iranian Traditional Medicine. In the present study, we evaluated the immune modulation and antioxidant effects of the hydroalcoholic extract of S.  variegata. Methods: The splenocytes were harvested...

background: umbilical cord blood (ucb) is an alternative source of hematopoietic stem cell transplantation (hsct), used in leukemia treatment. cd26+ cells, a fraction of cd34 positive cells, are a major population of ucb cells which negatively regulate the in vivo homing and engraftment of hscs. cd26 is highly expressed in various cells such as hscs, immune cells, fibroblasts, and epithelial ce...

Background Natural killer (NK) cells are immune that can detect and eliminate tumor bridge innate to adaptive responses. Tumor specific activation of NK is thus an area active investigation in oncology, but date has relied on complex biologic modalities (e.g., antibodies, fusion proteins, or cell therapies), each which inherent disadvantages this application. Thus, alternative approaches warran...

Familial hemophagocytic lymphohistiocytosis (FHLH) with Epstein–Barr virus (EBV) infection can mimic chronic active EBV of T- and NK-cell type (CAEBV-T/NK) in its clinical manifestation pathomorphology. FHLH genetic susceptibility to has not been previously reported. The development conjunction is rare needs further investigation understand characterize it. We report a case that mimicked CAEBV-...