Crk-associated substrate (Cas) lymphocyte-type (Cas-L) is a 105-kDa cytoplasmic protein consisting of Src homology-3 domain and multiple YXXP motifs (substrate domain). Our previous studies showed that Cas-L is tyrosine-phosphorylated following the ligation of TCR and beta 1 integrins in T lymphocytes. Here we show that Cas-L is involved in T cell motility following the ligation of TCR and beta...

The recent woes of the supercomputer industry and changes in federal funding have caused some scientists to re-evaluate the means by which they hope to solve Grand Challenge problems. I evaluate the potential of Massively Parallel Processors (MPP) within this context and the state of today's MPP. I stress that for solving large-scale problems MPP are crucial and that it is essential to seek a b...

Skin-lightening agents such as kojic acid, arbutin, ellagic acid, lucinol and 5,5′-dipropylbiphenyl-2,2′-diol are used in ‘anti-ageing’ cosmetics. Cases of allergic contact dermatitis caused by these skin-lightening agents have been reported (1, 2). Vitamin C and its derivatives have also been used in cosmetics as skin-lightening agents for a long time. Vitamin C in topical agents is poorly abs...

OBJECTIVES The main purpose of this study was to investigate whether carotid artery stenting (CAS) plus medicine in patients with severe carotid artery stenosis provide a better long-term blood pressure (BP) control compared to other medical treatments alone. The other aim was to explore the correlation between post-CAS hypotension within 6 h and long-term BP reductions after CAS. MATERIALS A...

Resistance to chemotherapy remains a major obstacle for the treatment of breast cancer. Understanding the molecular mechanism(s) of resistance is crucial for the development of new effective therapies to treat this disease. This study examines the putative role of p130(Cas) (Cas) in resistance to the cytotoxic agent Adriamycin. High expression of Cas in primary breast tumors is associated with ...

Résumé Le puisatier a pour profession le creusement et l'entretien des puits pour fournir de l'eau. Il est au contact de divers minerais, particulièrement la silice, particule qui présente un risque certain de développement des maladies pulmonaires connues sous le nom de silicose. Le but de notre travail est de préciser le profil épidémiologique, clinique, radiologique et évolutif des patients ...

(A histeria e as suas metamorfoses)Objetivo: Promover um pensamento investigativo acerca da evolução histórica dahisteria e de suas eventuais ramificações psicopatológicas nas classificações diagnósti-cas atuais. Método: Problematização histórica e clínica a partir do contraponto entrereferências clássicas e contemporâneas sobre o assunto. Conclusão: O aumento da inci-dência...

BACKGROUND Coronary artery ectasia (CAE) is a localized or diffuse abnormal dilatation of coronary arteries. Controversy still remains about its cardiovascular events rate, prognosis, and etiology. Adverse effects of CAE coinciding with coronary artery stenosis (CAS) (and in isolated form) are unclear. OBJECTIVES We aimed to investigate the cardiovascular event rate of CAE in comparison to 'C...

This paper describes the cunning ant system (cAS), which can be used to optimize problems with candidate solutions represented by permutations. cAS generates new candidate solutions from a combination of the pheromone density and the archive of past candidate solutions. Performance of cAS is demonstrated on two important classes of permutation problems: (1) the traveling salesman problem and (2...