BACKGROUND Elevated plasma homocysteine is a risk factor for Alzheimer disease, but the relevance of homocysteine lowering to slow the rate of cognitive aging is uncertain. OBJECTIVE The aim was to assess the effects of treatment with B vitamins compared with placebo, when administered for several years, on composite domains of cognitive function, global cognitive function, and cognitive agin...

The presence and pattern of iron accumulation in subcortical vascular mild cognitive impairment (svMCI) and their effects on cognition have rarely been investigated. We aimed to examine brain iron deposition in svMCI subjects using quantitative susceptibility mapping (QSM). Moreover, we aimed to investigate the correlation between brain iron deposition and the severity of cognitive impairment a...

BACKGROUND Several factors can interfere with the full physical and emotional growth of adolescents, among them chronic diseases. The aim was to determine the nutritional status of adolescents and to associate it with puberty, pancreatic sufficiency, lung function and age range of Cystic Fibrosis (CF) diagnosis. METHODS An observational, cross-sectional, retrospective and analytical study was...

OBJECTIVE The aim of this study was to examine the association between parental impulsivity and (12-15 year old) child body mass index (BMI). METHODS In total, 300 parents completed a survey regarding their own impulsivity level (Barratt impulsiveness scale) and that of their child (impulsivity scale of the temperament in middle childhood questionnaire), and supplied details of their own and ...

زمینه و هدف: بررسی دلایل ایجادکنندة ناباروری در مردان چگونگی جلوگیری از ایجاد جامعه، کمک ارزنده به بیمارانی است که رنج می‌برند. علل گوناگونی جمله سن، داروها، قرار گرفتن معرض سموم محیطی، مشکلات ژنتیکی بیماری‌های عمومی رخ می‌دهد. آسپرین (استیل سالیسیلک اسید: ASA) یکی داروهای ضدالتهابی غیراستروئیدی (NASID) جزء پرمصرف‌ترین جهان سبب کاهش توان باروری می‌شود. علاوه‌بر این فعالیت بدنی می‌تواند بر جنس ن...

OBJECTIVE The prevalence of obstructive sleep apnea-hypopnea syndrome (OSAHS) in the general pediatric population ranges from 1% to 3%. However, its prevalence in an unselected population of obese children is unknown. We studied the association between obesity and OSAHS in children diagnosed with the syndrome in a cohort of boys and girls (age range, 2-14 years) referred to the pediatric respir...

Background: Growth retardation is a long-term complication in pediatric transfusion-dependent thalassemias (TDTs), presented as short-stature and upper body segment shortening. The cause of this condition was chronic hypoxia, iron overload, endocrinopathy, inadequate transfusion, and iron chelation. We analyze the relationship between ferritin level and growth status of pediatric TDTs. Methods...

BACKGROUND Repetitive element DNA methylation is related to prominent obesity-related chronic diseases including cancer and cardiovascular disease; yet, little is known of its relation with weight status. We examined associations of LINE-1 DNA methylation with changes in adiposity and linear growth in a longitudinal study of school-age children from Bogotá, Colombia. METHODS We quantified met...

Background: The purpose of this study was to evaluate long-term changes in bone density profile among survivors of childhood acute lymphoblastic leukemia. Patients and Methods: This was a 5 year prospective study comprised of thirty-one survivors of childhood acute lymphoblastic leukemia with a mean age of 11.8 (4.6) years, who completed therapy at least 1 year previously (according to the ...