Hemodialysis (HD) is the most frequently used treatment for end-stage renal disease. Despite all efforts to improve the outcomes, the mortality of patients on HD is still high, and this is especially related to cardiovascular diseases (CVD). Glucose degradation products accumulate in plasma and tissue; such accumulation is strongly related to the risk of developing CVD. Tissue deposits of advan...

Snow-albedo feedback (SAF) is examined in 25 climate change simulations 5 participating in the Coupled Model Intercomparison Project version 5 (CMIP5). SAF 6 behavior is compared to the feedback’s behavior in the previous (CMIP3) generation of 7 global models. SAF strength exhibits a fivefold spread across CMIP5 models, ranging 8 from 0.03 to 0.16 W m−2 K−1 (ensemble-mean = 0.08 W m−2 K−1). Thi...

BACKGROUND Haemodialysis (HD) patients suffer from an increased risk of cardiovascular disease (CVD). Skin autofluorescence (SAF) is a strong marker for CVD. SAF indirectly measures tissue advanced glycation end products (AGE) being cumulative metabolites of oxidative stress and cytokine-driven inflammatory reactions. The dialysates often contain glucose. METHODS Autofluorescence of skin and ...

Angiogenesis plays a significant role in cancer by providing increased blood supply to the affected tissues and thus bringing in growth factors, cytokines, and various nutrients for tumor growth. VEGF is the most prominent angiogenic agent that is markedly induced in cancer. Induction of VEGF has been widely studied but as cancer cells are quite adept at acquiring new alternative processes to c...

Aim The Self-Adjusting File (SAF) system has been recommended for use in permanent teeth since it offers more conservative and effective root-canal preparation when compared to traditional rotary systems. However, no study had evaluated the usage of SAF in primary teeth. The aim of this study was to evaluate and compare the use of SAF, K file (manual instrumentation) and Profile (traditional ro...

Angiogenesis plays a significant role in cancer by providing increased blood supply to the affected tissues and thus bringing in growth factors, cytokines, and various nutrients for tumor growth. VEGF is the most prominent angiogenic agent that is markedly induced in cancer. Induction of VEGF has been widely studied but as cancer cells are quite adept at acquiring new alternative processes to c...

T he hunt for predictive biomarkers in diseases of the cardio-, cerebro-, and peripheral vascular systems is an ongoing effort and one whose importance cannot be overstated. The identification of subjects most at risk for death or major adverse cardiovascular events may provide a means to stratify diagnostic and therapeutic interventions based on validated predictive algorithms. In this issue o...

BACKGROUND Atrial fibrillation (AF) is commonly associated with impaired quality of life. There is no simple validated scale to quantify the functional illness burden of AF. The Canadian Cardiovascular Society Severity in Atrial Fibrillation (CCS-SAF) scale is a bedside scale that ranges from class 0 to 4, from no effect on functional quality of life to a severe effect on life quality. This stu...

This paper presents a dislocation-based yield strength model for the nano-indentation size effect. The is based on functional expressions involving densities of statistically stored dislocations and geometrically necessary dislocations. A single-phase austenitic stainless steel (316L) ferrite-austenite dual-phase (2205) are used here as case-study materials to validate proposed model. Experimen...