Deshpande et al. conclude that ethambutol (EMB) doses of 50 mg/kg of body weight twice a week would be the optimal clinical dose for the treatment of Mycobacterium avium (2). This was based on pharmacokinetic-pharmacodynamic studies using a hollow-fiber system model of intracellular M. avium, mimicking ethambutol human-like pharmacokinetics. This adds important information on the relationship b...

BACKGROUND Extraction of a broken tooth root is often a traumatic experience for both the practitioner and the patient. To extract broken roots, generally invasive approaches as open window surgeries or mucoperiosteal flap and/or removal of buccal bone are performed. PRESENTATION OF THE HYPOTHESIS Expandable micro-motor bur (EMB) is a hypothetical design of a dental instrument proposed for re...

Introduction Increasing drug resistance and poor activity of existing therapies towards the latent stage of Mycobacterium tuberculosis infection has produced a clear need to develop novel therapeutics to treat tuberculosis [1]. Thus fast-acting drugs with novel mechanisms of action that are not cross resistant to existing drugs are being sought actively. Wilkinson and coworkers first reported t...

The above core services will provide the basis of an electronic business system that will be available throughout Australia. As the system is developed, further services will be provided to ensure that Transigo remains current with the latest drvelopments in technology and business practice. A limited version of the scheme is alrcady in operation, and a public launch has been scheduled for earl...

The control of clamping force has a significant influence on the braking performance low-floor trams. However, load torque variations, strong nonlinearity and complex structure electromechanical brake (EMB) systems present challenging issues. In this paper, an EMB system mathematical model is established. Then, enhanced sliding-mode reaching law (ESMRL) investigated to address these addition, n...

Diagnosis The criterion for the diagnostic confirmation of myocarditis defined by 2013 European and Brazilian Myocarditis Guidelines is identification myocardial inflammation endomyocardial biopsy (EMB)., This criterion, used solely without option classifying clinical suspicion, does not mirror practice in real world, where only a minority patients specialized centers are referred investigation...