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nétics for prepackaged emergency contraceptive pills. The application was approved, and the company began marketing the product (under the trade name Preven) in September 1998. This development presumably indicates a more open and positive policy climate for emergency contraception, and the product should lead to standardization of postcoital contraception service delivery at the clinic level. ...

The c-Myc oncogenic transcription factor (Myc) is pathologically activated in many human malignancies. Myc is known to directly upregulate a pro-tumorigenic group of microRNAs (miRNAs) known as the miR-17–92 cluster. Through the analysis of human and mouse models of B cell lymphoma, we show here that Myc regulates a much broader set of miRNAs than previously anticipated. Unexpectedly, the predo...

Multitask Learning is an approach to inductive transfer that improves generalization by using the domain information contained in the training signals of related tasks as an inductive bias. It does this by learning tasks in parallel while using a shared representation; what is learned for each task can help other tasks be learned better. This paper reviews prior work on MTL, presents new eviden...

امروزه توسعه سیستم‌های کارآمد و اثربخش بهداشت درمان به یکی از نگرانی‌های اصلی دولت‌ها تصمیم‌گیرندگان تبدیل شده است. تأمین به‌موقع دارو کارایی سیستم موجودی توزیع، نقشی حیاتی در زنجیره بیمارستانی دارند برای افزایش این فعالیت‌ها، فرآیند تصمیم‌گیری مناسب مدیریت ضروری نظر می‌رسد. پژوهش یک مدل دوهدفه به‌صورت برنامه‌ریزی خطی عدد صحیح مختلط جریان اطلاعات ارائه اهداف حداقل­کردن هزینه‌های خرید، نگهداری، ...

نخستین گام در راستای تحلیل و ارزیابی ریسک‌های زنجیره تأمین شناسایی این ریسک‌ها است. روش‌های مرسوم بر اساس فیلترهای دستی یا خودکار داده‌­محور ارائه شده فیلتر به‌­دلیل محدودیت‌های نمونه‌گیری دارای مشکلات اعتبارسنجی هستند از طرف دیگر مبتنی داده، داده‌های ریسک که پیچیده مبهم هستند، عملکرد ضعیفی دارند. برای پرکرده خلل پژوهشی، پژوهش، چارچوبی تعاملی بین تحلیل‌­گر ماشین حجم وسیعی حوزه مواد غذایی با است...

This study aimed to investigate the effects of polymorphisms of the flavin-containing mono-oxygenase 3 (FMO3) and flavin-containing mono-oxygenase 6 (FMO6) genes on the pharmacokinetics of sulindac sulfide, the active metabolite of sulindac, in patients with preterm labor. Ten single-nucleotide polymorphisms (SNPs) were genotyped, and plasma sulindac sulfide concentrations were measured at 0, 1...

This study aimed to investigate the effects of polymorphisms of the flavin-containing mono-oxygenase 3 (FMO3) and flavin-containing mono-oxygenase 6 (FMO6) genes on the pharmacokinetics of sulindac sulfide, the active metabolite of sulindac, in patients with preterm labor. Ten single-nucleotide polymorphisms (SNPs) were genotyped, and plasma sulindac sulfide concentrations were measured at 0, 1...

On a nonstandard two-parametric quantum algebra and its connections with U p,q (gl(2)) and U p,q (gl(1|1)) Abstract. A quantum algebra U p,q (ζ, H, X ±) associated with a nonstandard R-matrix with two deformation parameters(p, q) is studied and, in particular, its universal R-matrix is derived using Reshetikhin's method. Explicit construction of the (p, q)-dependent nonstandard R-matrix is obta...