objective(s): nowadays, cancer is an important public health problem in all countries. limitations of current chemotherapy for neoplastic diseases such as severe adverse reactions and tumor resistance to the chemotherapeutic drugs have been led to a temptation for focusing on the discovery and development of new compounds with potential anticancer activity.   materials and methods: a new series...

In the context of general demand cost sharing, we present the first group-strategyproof mechanisms for the metric fault tolerant uncapacitated facility location problem. They are (3L)-budget-balanced and (3L · (1 +Hn))-efficient, where L is the maximum service level and n is the number of agents. These mechanisms generalize the seminal Moulin mechanisms for binary demand. We also apply this app...

1. Definitions and general properties. Let X be a compact topological space. Definition 1. For any open cover 31 of X let N(ñ) denote the number of sets in a subco ver of minimal cardinality. A subco ver of a cover is minimal if no other subcover contains fewer members. Since X is compact and 31 is an open cover, there always exists a finite subcover. To conform with prior work in ergodic theor...

I. E. Khodasevych, I. V. Shadrivov, D. A. Powell, W. S. T. Rowe, and A. Mitchell School of Electrical and Computer Engineering, RMIT University, Melbourne, VIC 3001, Australia ARC Centre for Ultrahigh bandwidth Devices for Optical Systems (CUDOS), Melbourne, VIC 3001, Australia Nonlinear Physics Centre, Research School of Physics and Engineering, Australian National University, Canberra, ACT 02...

This study documents that chlorinated analogs of leukotoxin diol 1, in which the vic-diol has been replaced with vic-chlorides (2), induce caspase 3 activity and apoptosis on HepG2 cells in a dose-dependent manner in analogy to the parent diol. This suggests that chlorides may substitute for hydroxyls in certain lipids as bioisosteres in defined biological settings.

Main Article: Reflection on the Development of a Research Agenda in Rural Health Lisa Bourke Department of Rural Health, The University of Melbourne PO Box 6500, Shepparton, VIC 3632, AUSTRALIA [email protected] James D. Best Lee Kong Chian School of Medicine Nanyang Technological University, Novena Campus 11 Mandalay Road, SINGAPORE 308232 [email protected] John Wakerman Faculty of Medi...

The regulation of phosphate (Pi) handling is crucial during calcification of the aortic valve. Gene profiling of Pi transporters revealed that VIC culture expresses SLC201A1/Pit1 and SLC20A2/Pit2. On exposure to a mineralizing medium (2 mM Pi), the expression of Pi transporters in VIC culture is increased several folds, with the highest magnitude for SLC20A1. By using siRNAs, we established tha...

Dustin J. Flanagan,1,2,10 Toby J. Phesse,3,10,11 Nick Barker,4,5,10 Renate H.M. Schwab,1,2 Nancy Amin,1,2 JordaneMalaterre,6 Daniel E. Stange,7 Cameron J. Nowell,3 Scott A. Currie,1,2 Jarel T.S. Saw,1,2 Eva Beuchert,1,2 Robert G. Ramsay,6 Owen J. Sansom,8 Matthias Ernst,3,11 Hans Clevers,7 and Elizabeth Vincan1,2,9,* 1Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, V...

Heart valve disease is an important cause of morbidity and mortality worldwide. Little is known about valve disease pathogenesis, but increasing evidence implicates a genetic basis for valve disease, suggesting a developmental origin. Although the cellular and molecular processes involved in early valvulogenesis have been well described, less is known about the regulation of valve extracellular...