A Stochastic Kinetic Model (SKM) is a continuous-time pure jump process describing the dynamic evolution of the state of the molecular network, x(t). Any change in x(t) is the result of the occurrence of some biochemical reaction, m. The stoichiometric matrix is given by S := [S1, S2, ..., SM ], where the column vector Sm consists of the changes in the number of molecules of each species caused...

OBJECTIVE Myelodysplastic syndromes (MDS) are a heterogenous group of clonal hematopoietic stem cell disorders characterized by increased risk of leukemic transformation. This study identifies microRNAs(miRNA) and miRNA targets that might represent leukemic transformation markers for MDS. METHODS Based on our previously established nested case-control study cohort of MDS patients, we chose pa...

Thyroid hormone (TH) plays a fundamental role in thermoregulation, yet the molecular mediators of its effects are not fully defined. Recently, skeletal muscle (SKM) uncoupling protein (UCP) 3 was shown to be an important mediator of the thermogenic effects of the widely abused sympathomimetic agents 3,4-methylenedioxymethamphetamine (MDMA; Ecstasy) and methamphetamine. Expression of UCP3 is reg...

Imbalance between nutritional intake and energy expenditure has been described to culminate in obesity, which predisposes to insulin resistance and type 2 diabetes mellitus. In such states of energy oversupply, excess amounts of lipids are available in tissues and circulation. Over the past years, an increasingly important role in development of skeletal muscle (SkM) insulin resistance has been...

Type 2 deiodinase (D2) converts the prohormone thyroxine (T4) to the metabolically active molecule 3,5,3'-triiodothyronine (T3), but its global inactivation unexpectedly lowers the respiratory exchange rate (respiratory quotient [RQ]) and decreases food intake. Here we used FloxD2 mice to generate systemically euthyroid fat-specific (FAT), astrocyte-specific (ASTRO), or skeletal-muscle-specific...

Recently, we used an ADP recycling approach to examine mouse skeletal muscle (SkM) mitochondrial function over respiratory states intermittent between state 3 and 4. We showed that respiration energized at complex II by succinate, in the presence of rotenone to block complex I, progressively increased with incremental additions of ADP. However, in the absence of rotenone, respiration peaked at ...

Apart from cytokines and chemokines, sphingolipid mediators, particularly sphingosine-1-phosphate (S1P) ceramide 1-phosphate (C1P), contribute to cancer inflammation. Cancer, as well other inflammatory conditions, are associated with skeletal muscle (SkM) atrophy, which is characterized by the unbalance between protein synthesis degradation. Although signaling pathways involved in SkM mass wast...

Çalışma, bazı Macar fiği genotiplerinin tohum ve kes verimleri ile kalitelerinin belirlenmesi amacıyla, 2014, 2015 2016 yıllarında 3 yıl süre yürütülmüştür. Çalışmada, bitki materyali olarak 10 adet genotipi kullanılmıştır. Araştırma tesadüf blokları deneme desenine göre üç tekrarlamalı kurulmuştur. Araştırmada; genotiplerin verimi, bin tane ağırlığı, keslerin ham kül oranı, protein oranı asit ...

Australian Hardboards (AHL) own and operate a wet process hardboard manufacturing plant in Queensland, Australia, that generates a significant quantity of process water effluent during the production of Masonite. AHL management recognised that there were significant opportunities to reduce water and energy usage in the process without adversely affecting product quality. Sinclair Knight Merz (S...