To the Editor: Comparisons of the Vitros ECi thyroid-stimulating hormone (TSH) method with the AxSym (1 ), Immulite (1, 2), Elecsys (2 ), and ADVIA Centaur (2 ) have shown an unexplained progressive negative bias ,0.2 mIU/L, a phenomenon that we have also observed (Fig. 1A). To investigate the bias, we diluted the TSH International Reference Preparation 80/558 (predominately pituitary TSH) and ...

Macro thyroid-stimulating hormone (TSH) has been reported to be associated with seasonality and regulated by changes in day length in rodents, different from free TSH. In the present study, we investigated structural differences between macro TSH and free TSH levels in human serum, as well as the association of macro TSH with sleep quality. We enrolled 314 patients registered in the Hyogo Sleep...

We encountered a 60-year-old woman with remarkably elevated thyroid-stimulating hormone (TSH) level as measured by electrochemiluminescent immunoassay (ECLIA), but with no specific symptoms, and with normal levels of free T3 and free T4. We performed the following investigations: polyethylene glycol (PEG) precipitation test, human antimouse IgG antibody (HAMA) interference test, and 3 additiona...

BACKGROUND Thyroid hormone is a central regulator of body functions. Disorders of thyroid function are considered to be a cause of electrolyte disorders. Only few data on the association between thyroid function and electrolyte disorders exists. METHODS In the present retrospective analysis data from all patients admitted to the Department of Emergency Medicine of a university hospital who ha...

UNLABELLED Elevated thyroid-stimulating hormone (TSH) was discovered by routine neonatal screening in a newborn with no clinical symptoms. Thyroid function tests were repeated and confirmed a high TSH value but normal total thyroxine (T4) and triiodothyronine (T3). However, the mother also had elevated serum TSH with normal levels of T4 and T3. The results suggested a transmitted maternal inter...

The well known effect of T4 administration is suppression of TSH level in plasma; with small doses of T4 has been shown to potentiate goitrogenesis induced by goitrogenic drugs. The effects of hort term treatment with sm3.11doses of T4 on plasma and pituitary TSH levels were studied in mice, Very sm3.11doses of T4 caused an increase in circulating TSH while larger dose produced the usual decrea...

BACKGROUND Basal TSH levels reflect the metabolic status of thyroid function, however the definition and interpretation of the basal levels of TSH is a matter of controversial debate. The aim of this study was to evaluate basal TSH levels in relation to the physiological response to i.v. TRH stimulation. METHODS A series of 2570 women attending a specialized endocrine unit were evaluated. A s...

Little is known about thyrotropin (TSH) and thyroid hormones in euthyroid Hashimoto's thyroiditis (HT), thus the aim was to investigate TSH and thyroid hormone economy in euthyroid HT and its relation to thyroid function. Ninety-five patients with euthyroid HT with normal TSH and thyroid hormones on the last follow up between 2009 and 2011 were investigated. Previous observation period ranged f...

The relationship between thyroid plasma membrane phosphorylation and thyrotropin (TSH) receptor degradation was investigated by using bovine thyroid tissues. By fractionation of thyroid cytosol (105,000 X g supernatant of thyroid homogenate) in a continuous sucrose density gradient centrifugation, three different TSH binding activities were separated. During the incubation of thyroid plasma mem...

Thyrotropin [thyroid-stimulating hormone (TSH)] receptor on-off signaling was studied in polarized monolayers of pig thyrocytes cultured on permeable support. Transepithelial resistance (R) and potential difference (PD) were used as parameters to monitor the effect of altered TSH concentrations on vectorial electrolyte transport. TSH induced rapid but long-lasting changes in R (decrease) and PD...