نتایج جستجو برای: ژن homer 1a
تعداد نتایج: 48605 فیلتر نتایج به سال:
Alexander P. McCauley,1 M. T. Homer Reid,1,2 Matthias Krüger,1 and Steven G. Johnson3 1Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA 2Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA 3Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, U...
Drug addiction involves complex interactions between pharmacology and learning in genetically susceptible individuals. Members of the Homer gene family are regulated by acute and chronic cocaine administration. Here, we report that deletion of Homer1 or Homer2 in mice caused the same increase in sensitivity to cocaine-induced locomotion, conditioned reward, and augmented extracellular glutamate...
Although Pindar's Homer began its life as the Mary Flexner Lectures in the Humanities at Bryn Mawr College in 1982, it clearly represents far more than a revised transcript of that event. The book looks more like a lifetime's work: over five hundred pages, elegantly produced with expansive footnotes and copious bibliography, wrapped in a glossy black dustjacket that gives it an authoritative, i...
Fragile X (FRAX) syndrome is a common inherited form of mental retardation resulting from the lack of fragile X mental retardation protein (FMRP) expression. The consequences of FMRP absence in the mechanism underlying mental retardation are unknown. Here, we tested the hypothesis that glutamate receptor (GluR) expression might be altered in FRAX syndrome. Initial in situ hybridization and West...
Homer is a family of cytoplasmic adaptor proteins that play different roles in cell function, including the regulation of G-protein-coupled receptors. These proteins contain an Ena (Enabled)/VASP (vasodilator-stimulated phosphoprotein) homology 1 domain that binds to the PPXXF sequence motif, which is present in different Ca²⁺-handling proteins such as IP3 (inositol 1,4,5-trisphosphate) recepto...
Motif discovery is one of the most challenging problems in bioinformatics today. DNA sequence motifs are becoming increasingly important in analysis of gene regulation. Motifs are short, recurring patterns in DNA that have a biological function. For example, they indicate binding sites for Transcription Factors (TFs) and nucleases. There are a number of Motif Discovery algorithms that run seque...
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