نتایج جستجو برای: ژن pgc

تعداد نتایج: 19502  

Journal: :American journal of translational research 2017
Wei Yuan Shoaib Ahmad Ajaz Najar

Morin exerts inhibitory effects on hepatic stellate cell (HSC) stimulation which is considered important step for fibrogenesis in liver. These morin-induced inhibitory effects are mediated through enhancement in the expression levels of peroxisome proliferator-activated receptor-γ (PPARγ). PPARγ plays a critical role in inhibition of HSC stimulation. Peroxisome proliferator-activated receptor-γ...

Journal: :American journal of physiology. Cell physiology 2010
Tuoyu Geng Ping Li Mitsuharu Okutsu Xinhe Yin Jyeyi Kwek Mei Zhang Zhen Yan

Endurance exercise stimulates peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) expression in skeletal muscle, and forced expression of PGC-1alpha changes muscle metabolism and exercise capacity in mice. However, it is unclear if PGC-1alpha is indispensible for endurance exercise-induced metabolic and contractile adaptations in skeletal muscle. In this study, we s...

Journal: :Nature communications 2016
Koichi Hasegawa Toru Yasuda Chinatsu Shiraishi Kazushiro Fujiwara Serge Przedborski Hideki Mochizuki Kazuaki Yoshikawa

Neurons rely heavily on mitochondria for their function and survival. Mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases such as Parkinson's disease. PGC-1α is a master regulator of mitochondrial biogenesis and function. Here we identify necdin as a potent PGC-1α stabilizer that promotes mitochondrial biogenesis via PGC-1α in mammalian neurons. Expression of...

Journal: :Cell metabolism 2006
Patrick Weydt Victor V Pineda Anne E Torrence Randell T Libby Terrence F Satterfield Eduardo R Lazarowski Merle L Gilbert Gregory J Morton Theodor K Bammler Andrew D Strand Libin Cui Richard P Beyer Courtney N Easley Annette C Smith Dimitri Krainc Serge Luquet Ian R Sweet Michael W Schwartz Albert R La Spada

Huntington's disease (HD) is a fatal, dominantly inherited disorder caused by polyglutamine repeat expansion in the huntingtin (htt) gene. Here, we observe that HD mice develop hypothermia associated with impaired activation of brown adipose tissue (BAT). Although sympathetic stimulation of PPARgamma coactivator 1alpha (PGC-1alpha) was intact in BAT of HD mice, uncoupling protein 1 (UCP-1) indu...

2018
Richard Mills Hermes Taylor-Weiner Jorge C. Correia Leandro Z. Agudelo Ilary Allodi Christina Kolonelou Vicente Martinez-Redondo Duarte M.S. Ferreira Susanne Nichterwitz Laura H. Comley Vanessa Lundin Eva Hedlund Jorge L. Ruas Ana I. Teixeira

OBJECTIVE We examined whether skeletal muscle overexpression of PGC-1α1 or PGC-1α4 affected myokine secretion and neuromuscular junction (NMJ) formation. METHODS A microfluidic device was used to model endocrine signaling and NMJ formation between primary mouse myoblast-derived myotubes and embryonic stem cell-derived motor neurons. Differences in hydrostatic pressure allowed for fluidic isol...

2013
Li-Na Zhang Hua-Yong Zhou Yan-Yun Fu Yuan-Yuan Li Fang Wu Min Gu Ling-Yan Wu Chun-Mei Xia Tian-Cheng Dong Jing-Ya Li Jing-Kang Shen Jia Li

Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) has been shown to influence energy metabolism. Hence, we explored a strategy to target PGC-1α expression to treat metabolic syndromes. We developed a high-throughput screening assay that uses the human PGC-1α promoter to drive expression of luciferase. The effects of lead compound stimulation on PGC-1α expression in muscle cel...

2015
Qingbin Zhao Junfang Zhang Huifang Wang

Increasing evidences have accumulated that endothelial dysfunction is involved in the pathogenesis of hypertension. Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) has been identified as an essential factor that protects against endothelial dysfunction in vascular pathologies. However, the functional role of PGC-1α in hypertension is not well understood. Using an ad...

2015
Qingbin Zhao Junfang Zhang Huifang Wang

AngII (angiotensin II)-induced excessive ROS (reactive oxygen species) generation and proliferation of VSMCs (vascular smooth muscle cells) is a critical contributor to the pathogenesis of atherosclerosis. PGC-1α [PPARγ (peroxisome-proliferator-activated receptor γ) co-activator-1α] is involved in the regulation of ROS generation, VSMC proliferation and energy metabolism. The aim of the present...

Journal: :American journal of physiology. Renal physiology 1998
Fred Ivan Kvam Jarle Ofstad Bjarne M Iversen

The relationship between systemic blood pressure and glomerular capillary pressure (Pgc) in spontaneously hypertensive rats (SHR) during treatment with antihypertensive drugs is still unclear. The effects of an angiotensin-converting enzyme inhibitor (enalapril), two calcium channel antagonists (nifedipine and verapamil), and an α1-receptor blocker (doxazosin) on renal blood flow (RBF) autoregu...

2012
Kari T. Chambers Zhouji Chen Peter A. Crawford Xiaorong Fu Shawn C. Burgess Ling Lai Teresa C. Leone Daniel P. Kelly Brian N. Finck

PGC-1β plays pleiotropic roles in regulating intermediary metabolism and has been shown to regulate both catabolic and anabolic processes in liver. We sought to evaluate the effects of PGC-1β on liver energy metabolism by generating mice with postnatal, liver-specific deletion of PGC-1β (LS-PGC-1β(-/-) mice). LS-PGC-1β(-/-) mice were outwardly normal, but exhibited a significant increase in hep...

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