2014 A possible way to calibrate the Cesium 6S ~ 7S parity violating electric dipole amplitude E1 (p.v) is to make use of the ratio E1 (p.v )/M1 (h.f ) where M1 (h.f ) is the magnetic dipole amplitude induced by the hyperfine interaction V (h.f). We show by evaluating relativistic and many-body effects that M1 (h.f) is given, to better than 3.10-3, by the geometrical mean of the 6S and 7S hyper...

We carry out relativistic many-body calculations of the static and dynamic dipole polarizabilities of the ground 6s2 S0 and the first excited 6s6p P0 states of Yb. With these polarizabilities, we compute several properties of Yb relevant to optical lattice clocks operating on the 6s2 S0–6s6p P0 transition. We determine (i) the first four magic wavelengths of the laser field for which the freque...

In this contribution, we study several monocarbonyl-metal complexes in order to unravel the contribution of relativistic effects to the metal-ligand bond length and complexation energy. Using scalar density functional theory (DFT) constrained space orbital variation (CSOV) energy decomposition analysis supplemented by all-electron four-component DFT computations, we describe the dependency of r...

This research work focuses on the experimental investigation of indentation damage resistance and post-indented performance different stacking sequence glass/epoxy laminates using mechanical acoustic responses. The with sequence, namely [0]12, [0/90]6S, [+45/-45]6S [0/+45/-45/90]3S were subjected to normal inclined emission monitoring. Quasi-static (QSI) test was conducted center a hemispherica...

In this study, atmospheric radiative transfer model 6S was used to simulate the radioactive transfer process in the surface-atmosphere-sensor. An algorithm based on the look-up table (LUT) founded by 6S model was used to correct(HJ-1)CCD image pixel by pixel. Then, the effect of atmospheric correction on CCD data of HJ-1 satellite was analyzed in terms of the spectral curves and evaluated again...

The 5R thymine glycol (5R-Tg) DNA lesion exists as a mixture of cis-(5R,6S) and trans-(5R,6R) epimers; these modulate base excision repair. We examine the 7:3 cis-(5R,6S):trans-(5R,6R) mixture of epimers paired opposite adenine in the 5'-GTgG-3' sequence with regard to nucleotide excision repair. Human XPA recognizes the lesion comparably to the C8-dG acetylaminoflourene (AAF) adduct, whereas X...

A new C11-norisoprenoid derivative, sargassumone (1), has been isolated from Sargassum naozhouense together with six known norisoprenoids and a highly oxygenated cyclopentene: (2R,6S,8S,9S)-hexahydro-2,9-dihydroxy-4,4,8-trimethyl-6-acetyloxy-3(2H)-benzofuranone (2), (6S,8S,9R)-hexahydro-6,9-dihydroxy-4,4,8-trimethyl-2(2H)-benzofuranone (3), (6S,8S,9R)-hexahydro-6,9-dihydroxy-4,4,8-trimethyl-2(2...

A novel class of phthalimides functionalized with privileged scaffolds was designed, synthesized and evaluated as potential inhibitors of plasmepsin 2 (Ki: 0.99 ± 0.1 μM for 6u) and plasmepsin 4 (Ki: 3.3 ± 0.3 μM for 6t), enzymes found in the digestive vacuole of the plasmodium parasite and considered as crucial drug targets. Three compounds were identified as potential candidates for further d...

We investigated the effect of inactivated Bifidobacterium on the mRNA expression of TRAF6, GSK-3β, and microRNA-146a in lipopolysaccharide (LPS)-stimulated rat small intestinal epithelial cells (IEC-6s). IEC-6s were randomly divided into an LPS group, a culture supernatant group, and an inactivated bacteria group. After stimulation with LPS for 5 h, the three groups were treated as follows: the...

We previously reported the chemical synthesis of oligonucleotides containing thymine glycol, a major form of oxidative DNA damage. In the preparation of the phosphoramidite building block, the predominant product of the osmium tetroxide oxidation of protected thymidine was (5R,6S)-thymidine glycol. To obtain the building block of the other isomer, (5S,6R)-thymidine glycol, in an amount sufficie...