OBJECTIVE To evaluate the frequency of luteinizing hormone (LH) variant in males and females in West region of the Czech Republic. This species of mutated LH concerns borderline alterations in pituitary-gonadal function, including higher risk for the development of more aggressive forms of prostate carcinoma in males. METHODS The examined normal population consisted of randomly selected 82 ma...

BACKGROUND Luteinizing hormone-releasing hormone (LH-RH) plays a central role in the vertebrate reproduction by regulating gonadal activity. Based on its binding to pituitary LH-RH receptors, as well as to LH-RH receptors expressed on cancer cells, LH-RH agonists and antagonists have been developed for different therapeutic applications. OBJECTIVE/METHOD Here we give an overview of the most r...

Gonadotropin-releasing hormone (GnRH) 1 and 2 and luteinizing hormone (LH) receptors have been described in the gastrointestinal tract. We have previously demonstrated antibodies in serum against GnRH1 in patients with gastrointestinal dysfunction and diabetes mellitus, and antibodies against GnRH receptor, LH, and LH receptor in patients with infertility. The aim of this study was to search fo...

OBJECTIVE There are few clinical investigations on the hot flushes that develop during endocrine therapy for prostate cancer in Japan, although there are many reports in the Western countries. Therefore, we evaluated the incidence of hot flushes and the association between hot flushes and clinical characteristics of prostate cancer patients receiving endocrine therapy. PATIENTS AND METHODS Si...

A specific luteinizing hormone receptor (LHR) mRNA binding protein (LRBP) has been identified and purified. This LH receptor mRNA binding protein selectively binds to the polypyrimidine rich bipartite sequence in the coding region of the LHR mRNA and accelerates its degradation. In response to preovulatory LH surge, the LH receptor expression in the ovary undergoes downregulation by accelerated...

CONTEXT Endometrial maturation, important in the diagnosis of infertile couples, has been evaluated since 1950 using the Noyes criteria. Nevertheless, there is no consensus regarding the most suitable period of the luteal phase for performing the biopsy. OBJECTIVE This study evaluated the correlation between the histological dating of two endometrial biopsies performed in the same menstrual c...

Lesions of the lateral hypothalamus (LH) cause hypophagia. However, activation of glutamatergic neurons in LH inhibits feeding. These results suggest a potential importance for other LH neurons in stimulating feeding. Our current study in mice showed that disruption of GABA release from adult LH GABAergic neurons reduced feeding. LH GABAergic neurons project extensively to the paraventricular h...

with open hepatectomy. The indications for LH have gradually expanded, from local resection of benign neoplasms at the liver edge to hemihepatectomy and more extensive anatomical resections, segmentectomy for malignant neoplasms, and donor hepatectomy for liver transplantations. The numbers of LH procedures performed are increasing exponentially in surgical centers worldwide [1,2]. In some high...

To investigate endocrine mechanisms associated with the occasional occurrence of fertile oestrus during lactation in the high prolific Chinese Meishan (MS) breed, the incidence of oestrus and changes in plasma luteinizing hormone (LH) levels before and after oestradiol benzoate (OB, 15 micrograms/kg body weight) administration on day 22 was compared in 4 MS and 6 Large White (LW) sows. All sows...

The physiological role of luteinizing hormone-releasing hormone (LH-RH) in mediating the secretion of gonadotrophins is well established. However, administration of large doses of LH-RH produces a paradoxical anti-fertility effect. Thus, in women, agonists of LH-RH have been shown to inhibit ovulation (Nillius, Bergquist & Wide, 1978) and interfere with corpus luteum function (Casper & Yen, 197...