نتایج جستجو برای: کمپلکس polycomb repressive complex2
تعداد نتایج: 11703 فیلتر نتایج به سال:
The Polycomb-repressive complexes PRC1 and PRC2 play a key role in chromosome silencing induced by the non-coding RNA Xist. Polycomb recruitment is initiated by the PCGF3/5-PRC1 complex, which catalyzes chromosome-wide H2A lysine 119 ubiquitylation, signaling recruitment of other PRC1 complexes, and PRC2. However, the molecular mechanism for PCGF3/5-PRC1 recruitment by Xist RNA is not understoo...
Polycomb repressive complex 2 (PRC2) silences gene expression through trimethylation of K27 of histone H3 (H3K27me3) via its catalytic SET domain. A missense mutation in the substrate of PRC2, histone H3K27M, is associated with certain pediatric brain cancers and is linked to a global decrease of H3K27me3 in the affected cells thought to be mediated by inhibition of PRC2 activity. We present he...
Polycomb group proteins are epigenetic gene silencers that have been implicated in cancer development and stem cell maintenance. Biological and genetic studies indicate that PcG proteins exist in at least two separate protein complexes, polycomb-repressive complex 2 (PRC2) and polycomb-repressive complex 1 (PRC1), which act in concert to promote and maintain gene repression. EZH2, the catalytic...
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