The in vitro activity of R 51,211 (itraconazole, accepted generic name; Janssen Pharmaceutica, Beerse, Belgium), a new orally active triazole, was compared with those of two existing orally active azoles, ketoconazole and BAY n 7133, and a topical agent, Ro 14-4767/002. An agar dilution procedure (Kimmig agar) was performed with 148 isolates of pathogenic fungi. Incubation was at 30 degrees C f...

Using an induced network module analysis of the deregulated genes in bulk transcriptome dataset murine IMQ model and human psoriasis, we have identified HIF-1α (Hypoxia-inducible factor 1 alpha) as a central hub that links numerous psoriasis signature (e.g. S100A8, S100A9, NOS2, VEGFA, RORC, SERPINB3, etc.). In addition, showed significant positive correlation with key psoriasis-associated clin...