Introduction:  With repeated courses of chemotherapy, chemotherapy-induced nausea and vomiting (CINV) becomes progressively more difficult to control. The aim of this study was to evaluate whether the antiemetic efficacy of the triple combination aprepitant, palonosetron and dexamethasone could be sustained for up to six cycles of highly emetogenic chemotherapy (HEC) (cisplatin ≥ 50 mg/m(2) ). ...

Many cities have been built along large rivers. The rivers can provide a source of drinking water, act as receiving water for treated effluent, provide navigation for shipping, and other beneficial uses. However, the city must also be protected from flooding due to the close proximity to the river. Hydrologic analysis plays a crucial role in the development of plans for protecting a river city....

The aim of the present study was to determine the effect of cyclin‑dependent kinase 7 (CDK7) silencing on the sensitivity of the HEC‑1‑A endometrial carcinoma cell line to cisplatin [cis‑dichlorodiammineplatinum (II), or DDP]. Four CDK7 siRNA fragments were designed and synthesized based on the gene sequence of CDK7 and transfected into HEC‑1‑A cells. The RNA interference of the fragments was c...

Abstract DKI Jakarta is the capital city of Indonesia well known as a with most rapid development and growth in country. This indicates that increase population Jakarta, need for considerable change land use cannot be denied. Environmental problems will get worse over time have resulted flooding which has been concern local government every year. A polder system stated to effective resolving fl...

BACKGROUND Implantation in humans involves cross talk between an active blastocyst and receptive endometrium. The role of the endometrial receptors in this complex embryo-maternal interaction is still unclear. We tested gene and protein expression of endometrial receptors (Progesterone receptor (PR) and c-Met) and the effect of theses receptors in endometrial receptivity. METHODS Two endometr...

Vascular endothelial surface-related activities may depend on the lateral mobility of specific cell surface macromolecules. Previous studies have shown that cytokines induce changes in the morphology and surface antigen composition of vascular endothelial cells in vitro and at sites of immune and inflammatory reactions in vivo. The effects of cytokines on membrane dynamic properties have not be...

PURPOSE EphA2 overexpression is frequently observed in endometrial cancers and is predictive of poor clinical outcome. Here, we use an antibody drug conjugate (MEDI-547) composed of a fully human monoclonal antibody against both human and murine EphA2 (1C1) and the tubulin polymerization inhibitor monomethylauristatin F. EXPERIMENTAL DESIGN EphA2 expression was examined in endometrial cancer ...

Plant meristems carry pools of continuously active stem cells, whose activity is controlled by developmental and environmental signals. After stem cell division, daughter cells that exit the stem cell domain acquire transit amplifying cell identity before they are incorporated into organs and differentiate. In this study, we used an integrated approach to elucidate the role of HECATE (HEC) gene...

Endometrial carcinoma (EC) is a common malignancy of the female genital tract with a poor prognosis. It has been reported that miR-34c is significantly reduced in EC, but research concerning its function in EC is rare. In the present study, the expression of miR-34c was upregulated in the EC cell line, HEC-1-B, by transfecting the cells with hsa-miR-34c-5p mimics. Then, after determining the tr...

reliable estimates of river stream fl ow and fl ood zoning maps are needed for water resourcesmanagement such as fl ood mitigation, water supply, dam construction and irrigation. flood zoning needsaccurate data and is one of the non-structural fl ood management methods. this paper describes theapplication of hec-ras and gis model to determine fl oodplains maps for the part of sardabrud rivertha...