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Results Array-CGH analysis performed in a patient with multiple congenital anomalies and a recurrent fever syndrome revealed a de novo heterozygous chromosomal rearrangement encompassing a duplication of TNFRSF11A. This transmembrane receptor binds the TNFSF11 cytokine, activates NF-k B signaling, and regulates fever in rodents, consistent with a possible role in HRF. TNFRSF11A screening in oth...
BACKGROUND AGS-003 is an autologous immunotherapy prepared from fully matured and optimized monocyte-derived dendritic cells, which are co-electroporated with amplified tumor RNA plus synthetic CD40L RNA. AGS-003 was evaluated in combination with sunitinib in an open label phase 2 study in intermediate and poor risk, treatment naïve patients with metastatic clear cell renal cell carcinoma (mRCC...
Perceived Choices of Graduation among Master Students: Expectancy-Task Value Theoretical Perspective
This study investigated whether motivational beliefs (expectancy of success and value in research practice related tasks) among master students predict the achievement choices for graduation (thesis or non-thesis) examined likelihood those thesis non-thesis preferring group. Participants studied various programs two universities Cambodia completed questionnaires about their expectancy values to...
Osteonecrosis (ON) is characterized through the impairment of osseous blood flow that leads to the collapse of femur head. Corticoid-induced ON in rats and lipopolysaccharide (LPS)-induced in rabbits are useful models to assess the efficacy of potential treatments on this disease. D-003 inhibits the mevalonate pathway, lipid peroxidation and prevents osteoporosis in rats through increasing the ...
Introduction The daughter of a first-cousin marriage from Saudi Arabia died at age 7y/o of an unexplained periodic fever illness. At two years of age, the proband presented with recurrent fever attacks associated with febrile seizures, severe anemia, septic arthritis, diarrhea, and severe vomiting causing multiple ICU submissions. Considering her ancestry, she was thought to have an FMF-like di...
Applications in mobile multi-agent systems require a high degree of confidence that code that runs inside the system will not be malicious and that any agents which are malicious can be identified and contained. Since the inception of mobile agents, this threat has been addressed using a multitude of techniques, but many of these implementations have only addressed concerns from the position of...
Introduction Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is an autoinflammatory disease inherited in an autosomal dominant fashion. TRAPS develops secondary to mutations in TNFRSF1A. Associated symptoms include periodic attacks of peritonitis, constipation, arthritis in large joints, arthralgia, migratory rash with underlying myalgia, periorbital edema, conjunctivitis, s...
This paper presents VTMs (Vector Texture Maps), a novel representation of vector images that can be used as a texture by the GPU for real-time rendering. A VTM decomposes texture space into different regions, represented in an analytic way, by a set of implicit degree 3 polynomials. Each region can be rendered by a different fragment shading function. Accurate anti-aliasing is performed in real...
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