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BACKGROUND Published results from a controlled clinical trial in patients with peripheral arterial disease found improved outcomes with iron (ferritin) reduction among middle-aged subjects but not the entire cohort. The mechanism of the age-specific effect was explored. METHODS Randomization to iron reduction (phlebotomy, n = 636) or control (n = 641) stratified by prognostic variables permit...
TCTAP C-028 Inferior ST-elevated Myocardial Infarction Having Hard Time for Aspirating Hard Thrombus
In large-scale expression profiling analyses, we have previously identified genes differentially expressed between subclones of the pancreatic cancer cell line SUIT-2. One of the genes most strongly overrepresented in the highly metastatic subclone S2-007 as compared with the rarely metastatic subclone S2-028 was the serine proteinase inhibitor SERPINE2 (protease nexin I), suggesting that this ...
Introduction Cryopyrin-Associated Periodic Syndromes (CAPS) are a group of rare, inherited, autoinflammatory diseases involved of Familial Cold Autoinflammatory Syndrome (FCAS), Muckle-Wells Syndrome (MWS) and Neonatal Onset Multisystem Inflammatory Disease (NOMID) (also called Chronic Infantile Neurologic Cutaneous Articular, or CINCA, Syndrome. The responsible gene NLRP3 (nucleotide-binding d...
Collective decision making problems can be seen as finding an outcome that is “closest” to a concept of “consensus”. Nitzan (1981) introduced “Closeness to Unanimity Procedure” as a first example to this approach and showed that the Borda rule is the closest to unanimity under swap distance (a.k.a the Kemeny (1959) distance). Meskanen and Nurmi (2008) shows that the Dodgson rule is the closest ...
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