A 63-year-old Japanese woman with advanced lung adenocarcinoma developed isolated adrenocorticotropin deficiency caused by immune checkpoint inhibitor (ICI)-related hypophysitis following 8 months of nivolumab therapy. Prompt corticosteroid replacement therapy effectively relieved her secondary adrenal insufficiency symptoms and allowed her to pursue nivolumab therapy, which had been effective ...

Abstract Introduction Our objectives were to compare the 1‐year follow‐up clinical performance of TCu380A intrauterine device (TCu380A‐IUD) and levonorgestrel (LNG) 52‐mg system (IUS) inserted at post‐placental period. Material methods We conducted an open‐label, parallel‐group, randomized trial, 1:1 with pregnant women admitted for childbirth independently mode birth. primary outcome was expul...

BACKGROUND Dipeptidyl peptidase 4 (DPP4) and angiotensin-converting enzyme (ACE) are important target enzymes in glycemic control and renovascular protection. Here, we studied the effect of NWT-03, an egg protein hydrolysate with DPP4- and ACE-inhibitory activity, on renovascular damage in Zucker diabetic fatty (ZDF) rats. Comparisons were made to rats treated with vildagliptin (VIL), included ...

OBJECTIVE Type 1 diabetes mellitus (T1D) is an autoimmune and multifactorial disorder. Subsequent analysis on human leukocyte antigen ( HLA) region shows that HLA-DRB1 and -DQB1 genes have the strongest association with T1D. In this study, for the first time, we investigated the influence of gender on the HLA-DRB1 and -DQB1 association with type 1 diabetes mellitus in Iranian patients in order ...

Users expect applications to successfully cope with the expansion of information as necessitated by the continuous inclusion of novel types of content. Given that such content may originate from “not-seen thus far” data collections and/or data sources, the challenging issue is to achieve the return of investment on existing services, adapting to new information without changing existing busines...

The Rogers-Ramanujan identities have reached the ripe-old age of one hundred and five and are still the subject of active research. We will discuss their fascinating history, some of the number theory and combinatorics they encapture, and what they have to do with the 1998 Nobel Prize in physics. 1. The Rogers–Ramanujan identities In this lecture you will be introduced to the Rogers–Ramanujan i...

Der landwirtschaftliche Strukturwandel und nicht zuletzt auch die Ausweitung des Anbaus nachwachsender Rohstoffe für die energetische Nutzung haben in den vergangenen Jahrzehnten zu einer deutlichen Veränderung der Agrarlandschaft beigetragen und diese nachhaltig geprägt. Vor diesem Hintergrund beschäftigt sich die Forschungslinie '3D + t Landmodellierung' am Lehrstuhl für Geoinformatik der TU ...

Multiplex families with type 1 diabetes are important for identification of rare variants that cannot be identified in case-control association studies. The very low incidence of type 1 diabetes in the Japanese population, however, makes identification of such families difficult. We identified a Japanese family in which three members developed type 1 diabetes, and studied the genotype of the hu...