Lead (Pb) is a known nephrotoxicant that causes damage to proximal tubular cells. Autophagy has an important protective role in various renal injuries, but the role of autophagy in Pb-elicited nephrotoxicity remains largely unknown. In this study, Pb promoted the accumulation of autophagosomes in primary rat proximal tubular (rPT) cells, and subsequent findings revealed that this autophagosome ...

Sterile particles induce robust inflammatory responses that underlie the pathogenesis of diseases like silicosis, gout, and atherosclerosis. A key cytokine mediating this response is IL-1β. The generation of bioactive IL-1β by sterile particles is mediated by the NOD-like receptor containing a pyrin domain 3 (NLRP3) inflammasome, although exactly how this occurs is incompletely resolved. Prior ...

Pheromone-binding proteins (PBPs) of the gypsy moth, Lymantria dispar L., play an important role in olfaction. Here structures of PBPs were first built by Homology Modeling, and each model of PBPs had seven α-helices and a large hydrophobic cavity including 25 residues for PBP1 and 30 residues for PBP2. Three potential semiochemicals were first screened by CDOCKER program based on the PBP model...

Abstract. The availability of crop type reference datasets for satellite image classification is very limited complex agricultural systems as observed in developing and emerging countries. Indeed, land use dynamic, censuses are often poorly georeferenced types difficult to interpret directly from imagery. In this paper, we present a database made 24 collected standardized manner over nine sites...

Gene-environment (GxE) interactions are thought to play a role in the pathogenesis of atopic eczema, but specific genes and environmental factors remain be elucidated. We analysed data from 25 European studies 7 countries test for interaction between 24 loci identified by genome-wide association 10 early-life exposures, on eczema as an outcome. Fourteen 240 pairwise reached nominal significance...