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Psoriasis (PsO) is a T cell-mediated autoimmune disease without cure. The major risk-associated PsO susceptibility gene encodes for the human leukocyte antigen C*06:02 (HLA-Cw6). Half of patients carry this allele encoding HLA-I molecule which presents short peptides (together known as immunopeptidome) to CD8 cells, thereby initiating immune responses. It unclear presented by HLA-Cw6 are preval...
Yeast cells contain an RNA polymerase factor, pi, which is a heat-stable protein with an apparent molecular weight of 12,000. This factor stimulates transcription of calf-thymus, salmon-sperm, yeast-nuclear, and T4-phage DNA. It stimulates transcription by each of the four yeast-nuclear RNA polymerases, by rat-liver RNA polymerases I and II, and by Escherichia coli RNA polymerase. pi-Factor can...
Individuals who are heterozygous for the CCR5-Δ32 mutation provide a natural model to examine the effects of reduced CCR5 expression on human immunodeficiency virus (HIV) persistence. We evaluated the HIV reservoir in 18 CCR5-Δ32 heterozygotes and 54 CCR5 wild-type individuals during suppressive antiretroviral therapy. Cell-associated HIV RNA levels (P=.035), RNA to DNA transcriptional ratios (...
013 ACUTE KIDNEY INJURY IN NEUROCRITICAL PATIENTS - INCIDENCE, CLINICAL CHARACTERISTICS, AND OUTCOME
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