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Transforming growth factor-beta (TGF-beta) suppresses tumor formation by blocking cell cycle progression and maintaining tissue homeostasis. In pancreatic carcinomas, this tumor suppressive activity is often lost by inactivation of the TGF-beta-signaling mediator, Smad4. We found that human pancreatic carcinoma cell lines that have undergone deletion of MADH4 constitutively expressed high endog...
One mechanism of initiation and propagation atrial fibrillation (AF) may depend on rapid stimulation from focal sources. Whether arrhythmogenic at these foci is abnormal automaticity, triggered activity, or microreentry unclear; however, after activation emerges driver sites, fibrillatory conduction results in clinical AF. Electrographic Flow (EGF) mapping visualizes global wavefront near real-...
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