While certain antibodies directed against the human immunodeficiency virus (HIV) envelope have the potential to suppress virus replication in vitro, the impact of neutralizing antibodies in vivo remains unclear. In a recent proof-of-concept study, the broadly neutralizing monoclonal antibodies 2G12, 4E10, and 2F5 exhibited inhibitory activities in vivo, as exemplified by a delay of the viral re...

The anti-amyloid β monoclonal antibody aducanumab was approved on June 7, 2021, by the US Food & Drug Administration (FDA) for treatment of Alzheimer's disease.1 Approval provided under FDA's accelerated approval process drugs that treat serious conditions and fill an unmet need, based surrogate endpoint reduction amyloid plaques in brain.

Objetivos: el nivolumab es un anticuerpo monoclonal contra PD-L1 (programmed death receptor-1) usado como opción terapéutica en pacientes con cáncer de pulmón células no pequeñas (CPCNP) avanzado. Este estudio tuvo objetivo evaluar la experiencia segunda (2L) y tercera línea (3L) tratamiento CPCNP avanzado, diferentes centros oncológicos Colombia.

Both a murine monoclonal antibody to phosphatidylinositol phosphate (PIP) and a human monoclonal antibody (4E10) that is known to have broadly neutralizing capabilities against primary isolates of human immunodeficiency virus type 1 (HIV-1) bound to PIP, as determined by enzyme-linked immunosorbent assay. Each of the antibodies had antigen subsite binding specificities in aqueous medium for sma...

BACKGROUND Smoldering multiple myeloma (SMM) is an indolent disease stage, considered to represent the transition phase from the premalignant MGUS (Monoclonal Gammopathy of Undetermined Significance) state towards symptomatic multiple myeloma (MM). Even though this diagnosis provides an opportunity for early intervention, few treatment studies have been done and the current standard of care is ...

in this study 19 blv infected and 2 healthy lymph nodes were analysed by western blotting to detect viral p 24 antigen . western blotting was carried out by rabbit anti p24 serum and p24 monoclonal antibody. rabbit serum in western blotting could detect 45, 50, 54, 58 and less than 19 kd bands of proteins and monoclonal antibody could detect 30, 32, 39, 45, 50 and 53 kd bands. our results indic...