Tobacco leaves are large and have sticky exudates that retain the radon decay products once they deposit on the leaves. The study of Po in tobacco is required, because of the cumulative alpha-radiation dose delivered to humans from inhaled Po in cigarette smoke. Pb is the other element of interest since it is the Po precursor in the radioactive decay chain. In the present study, the concentrati...

5-Hydroxytryptamine (5-HT) is involved in mammalian thermoregulation of the preoptic anterior hypothalamus (PO/AH), but the underlying molecular mechanisms are not fully understood. In this study, we investigated the influence of 5-HT and agonists and antagonists of the 5-HT1A, 5-HT2A, 5-HT3 and 5-HT7 receptors on voltage-gated calcium currents in the PO/AH slice with the whole-cell patch clamp...

We have further characterized at the single channel level the properties of epithelial sodium channels formed by coexpression of alpha with either wild-type beta or gamma subunits and alpha with carboxy-terminal truncated beta (betaT) or gamma (gammaT) subunits in Xenopus laevis oocytes. alphabeta and alphabetaT channels (9.6 and 8.7 pS, respectively, with 150 mM Li+) were found to be constitut...

BACKGROUND This is the first study to compare plasma and cerebrospinal fluid (CSF) pharmacokinetics of intravenous (IV), oral (PO), or rectal (PR) formulations of acetaminophen. METHODS Healthy male subjects (N = 6) were randomized to receive a single dose of IV (OFIRMEV(®) ; Cadence) 1,000 mg (15 minute infusion), PO (2 Tylenol(®) 500 mg caplets; McNeil Consumer Healthcare), or PR acetaminop...

Mathematical simulations of oxygen delivery to tissue from capillaries that take into account the particulate nature of blood flow predict the existence of oxygen tension (Po(2)) gradients between erythrocytes (RBCs). As RBCs and plasma alternately pass an observation point, these gradients are manifested as rapid fluctuations in Po(2), also known as erythrocyte-associated transients (EATs). Th...

In this article, we consider various arithmetic properties of the function po(n) which denotes the number of overpartitions of n using only odd parts. This function has arisen in a number of recent papers, but in contexts which are very different from overpartitions. We prove a number of arithmetic results including several Ramanujan-like congruences satisfied by po(n) and some easily-stated ch...

OBJECTIVE To determine the accuracy of heart rate obtained by pulse oximetry (HR(PO)) relative to HR obtained by 3-lead electrocardiography (HR(ECG)) in newborn infants in the delivery room. STUDY DESIGN Immediately after birth, a preductal PO sensor and ECG leads were applied. PO and ECG monitor displays were recorded by a video camera. Two investigators reviewed the videos. Every two second...

OBJECTIVE To compare the effectiveness of preoperative PO and SC administration of buprenorphine and meloxicam for prevention of postoperative pain-associated behaviors in cats undergoing ovariohysterectomy. DESIGN Randomized controlled study. ANIMALS 51 female cats (4 to 60 months old; weight range, 1.41 to 4.73 kg [3.1 to 10.4 lb]). PROCEDURE Cats received 1 of 5 treatments at the time ...

BACKGROUND Posaconazole is the most active available azole antifungal drug, but absorption and pharmacokinetics are not available to guide dosing regimens in cats. OBJECTIVE To determine the pharmacokinetics of posaconazole in cats given an IV solution and PO suspension. ANIMALS Six healthy, adult research cats. METHODS After a 12-hour fast, each cat received 15 mg/kg of posaconazole PO s...

A scanning phosphorescence quenching microscopy technique, designed to prevent accumulated O(2) consumption by the method, was applied to Po(2) measurements in mesenteric tissue. In an attempt to further increase the accuracy of the measurements, albumin-bound probe was topically applied to the tissue and an objective-mounted pressurized bag was used to reduce the oxygen transport bypass throug...