BACKGROUND Dietary n-3 polyunsaturated fatty acids improve brain functioning in animal studies, but there is limited study of whether this type of fat protects against Alzheimer disease. OBJECTIVE To examine whether fish consumption and intake of different types of n-3 fatty acids protect against Alzheimer disease. DESIGN Prospective study conducted from 1993 through 2000, of a stratified r...

Absence [ZBK06]. Absorbers [MS08]. Accelerated [AVE08, AL14, CWD08]. Account [SSJ12]. Accounting [BFRD13]. Accuracy [Aar04, Str05, VO13, VVVR07]. Accurate [ACHR06, CTL16, CR06]. Acoustic [BIT10, CS14, HMS14, LLZ14, LR10a, VMK05]. Across [AD16, Fan09, Rob09]. Active [HL10a]. Activities [LYTP13]. Activity [BRR13, GSF09]. Adaptive [AE06, AB15a, BCK05, CDG14, EGM13, FYW11, HOS14, JLT04, KJ16, KN06,...

Directed conversion of mature human cells, as from fibroblasts to neurons, is of potential clinical utility for neurological disease modeling as well as cell therapeutics. Here, we describe the efficient generation of human-induced neuronal (hiN) cells from adult skin fibroblasts of unaffected individuals and Alzheimer's patients, using virally transduced transcription regulators and extrinsic ...

Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common form of dementia. Almost 47 million people suffer from dementia worldwide. AD accounts for approximately 60%–80% of all dementia cases. Three major pathologies characterize the disease: senile plaques, neurofibrillary tangles and inflammation. We review the literature on events contributing to the inflammat...

PURPOSE Alzheimer s disease is characterized by a dysfunction of central cholinergic systems and is treated by inhibitors of acetylcholinesterase (AChE). This study tests the effect of two AChE inhibitors in therapeutic use, rivastigmine and donepezil, in mice that are devoid of AChE (AChE-/- mice). Rivastigmine is an inhibitor of both AChE and butyrylcholinesterase (BChE) whereas donepezil is ...

Mitochondrial DNA (mtDNA) is highly polymorphic, and its variations in humans may contribute to individual differences in function as well as susceptibility to various diseases such as Parkinson disease, Alzheimer disease, bipolar disorder, and cancer. However, it is unclear whether and how mtDNA polymorphisms affect intracellular function, such as calcium signaling or pH regulation. Here we se...

BACKGROUND Although risk factors for Alzheimer disease have been well studied, much less is known about risk factors for primary progressive aphasia (PPA). OBJECTIVE To demonstrate that learning disabilities (LDs) are more common in patients with PPA and their first-degree family members. DESIGN, SETTING, AND PATIENTS Self-report endorsement of an individual and family history of an LD in a...