There is increasing evidence to indicate that insulin‑like growth factor (IGF)‑1 plays a crucial role in the regeneration of different tissues following injury. Notably, despite escalating number animal studies, studies investigating IGF‑1 wound healing process humans are fewer. In this context, aim present study was evaluate variations expression isoforms (IGF1‑Ea, IGF1‑Eb and IGF1‑Ec), as wel...

Background: Morphine is wildly used as a painkiller in clinics, but causes several side effects such as hyperalgesia, depression and more notably amnesia. Here, we assumed that insulin-like Growth Factor-1 (IGF-1) as a peptide with widespread distribution of receptors in brain regions, especially hippocampus, might be capable to alleviate morphine-induced amnesia. Meth...

The present study was conducted to evaluate the expression of caspase-3, caspase-9, growth differentiation factor-9 (GDF-9) and insulin factor-1 (IGF-1) genes in oocytes cultured vitro with optimum elevated doses amphiregulin (50 ng 150 ng), neuregulin-1 (25 ng) tumor necrosis factor-α during maturation based on results effects AREG or NRG-1 TNF-α concentration which caused significant effect, ...

AIMS To establish that cells from the murine mammary carcinoma cell line, EMT6, express type I insulin-like growth factor receptor (IGF-IR), tissue-type plasminogen activator (tPA), and urokinase-type plasminogen activator (uPA). To investigate the role of IGF-IR in growth, transformation, and tumorigenesis in addition to its relation to tPA and uPA in EMT6 cells. To assess the suitability of t...

We tested the hypothesis that older men (n = 9, 69 +/- 2 years) would experience greater resistance-training-induced myofiber hypertrophy than older women (n = 5, 66 +/- 1 years) following knee extensor training 3 days per week at 65-80% of one-repetition maximum for 26 weeks. Vastus lateralis biopsies were analyzed for myofiber areas, myosin heavy chain isoform distribution, and levels of mRNA...

BACKGROUND Klotho, as a new anti-aging gene, can shed into circulation and act as a multi-functional humoral factor that influences multiple biological processes. Recently, published studies suggest that klotho can also serve as a potential tumor suppressor. The aim of this study is to investigate the effects and possible mechanisms of action of klotho in human lung cancer cell line A549. MET...

growth hormone and insulin-like growth factor 1 are anabolic hormones which play a vital role in developing body tracts especially in childhood and adolescence years. exercise is a motive which influences gh and igf-1 secretion. today, water sports are highly recommended due to creating delight in children. therefore, the purpose of this study was to examine the effect of eight weeks of water t...