UNLABELLED We were interested in determining whether rostral medial prefrontal cortex (rmPFC) neurons participate in the measurement of conditioned stimulus-unconditioned stimulus (CS-US) time intervals during classical eyeblink conditioning. Rabbits were conditioned with a delay paradigm consisting of a tone as CS. The CS started 50, 250, 500, 1000, or 2000 ms before and coterminated with an a...

Monitoring Stations Spatial (*) Temporal (**) OSTK (a) OSTK (b) OSTK (c) OFK (d) MS 1 0.437565 0.622622 0.239840 0.231035 0.209881 0.235384 MS 3 0.224087 0.791143 0.182182 0.146736 0.122645 0.345274 MS 4 0.625908 0.994427 0.213238 0.166578 0.144406 0.268091 MS 5 0.331003 0.930160 0.282285 0.250859 0.226962 0.074164 MS 6 0.519234 0.593884 0.232473 0.220146 0.196527 0.385527 MS 7 0.326360 0.63487...

Achievable resolution and spurious performance of analog-to-digital converters (ADCs) are tightly connected to the maximum sampling frequency of the device. Today, in early 2013, sampling rates of commercially available 16-bit monolithic, single-core (non-interleaved) ADCs are limited to 250 MS/s while 14-bit ADCs can be found up to 400 MS/s. The corresponding number for a single-core 12-bit AD...

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. A 40-year-old female patient with a 12-year history of MS was admitted to our clinic with blurred vision and floaters in her right eye for about 1 month. Here, we share the findings and the management of intermediate uveitis and retinal periphlebitis in an MS case being treated with interferon...

OBJECTIVES To evaluate multiple sclerosis (MS)-related health care-resource utilization and costs prior to and after initiating natalizumab in the US. MATERIALS AND METHODS A retrospective administrative claims analysis was conducted using the Truven Health MarketScan Databases to identify adults diagnosed with MS who initiated natalizumab (index date) between January 1, 2007 and December 31,...

This paper describes the implementation of a 12-bit 230 MS/s pipelined ADC using a conventional 1.8V, 0.18μm digital CMOS process. Two-stage folded cascode OTA topology is used for improved settling performance. Extreme low-skew (less than 3ps peak-to-peak) chip-level clock distribution is ensured by five-level balanced clock tree, implemented in low swing current-mode logic. The ADC block achi...

PURPOSE To study healing of retinal laser lesions in patients undergoing PRP using SD-OCT. METHODS Moderate, light and barely visible retinal burns were produced in patients with proliferative diabetic retinopathy scheduled for PRP using 100-, 20- and 10-ms pulses of 532-nm laser, with retinal spot sizes of 100, 200 and 400 μm. Lesions were measured with OCT at 1 hr, 1 week, 1, 2, 4, 6, 9 and...

Abstract During the last decades we have witnessed performance improvement and aggressive growth of complexity integrated circuits (ICs). The progressive size reduction transistors in recent technological nodes has allowed even compelled IC designers to perform analog tasks digital domain, increasing demand for analog-to-digital converters (ADCs). This work presents design implementation a low ...

multiple sclerosis (ms) is a complex disease resulting from the occurrence of intermingled episodes of neuro-inflammation and degeneration. the temporal and spatial patterns in which these events occur are not well understood as well as the molecular substrates underlying it. myelin loss and gain, as well as axonal damage are considered crucial events influencing the course of the disease but t...