The study of microbial pangenomes relies on the computation of gene families, i.e. the clustering of coding sequences into groups of essentially similar genes. There is no standard approach to obtain such gene families. Ideally, the gene family computations should be robust against errors in the annotation of genes in various genomes. In an attempt to achieve this robustness, we propose to clus...

What is the effect of the AFDC-Unemployed Parent (UP) program on two-parent families? This question has become particularly relevant following the passage of the Family Support Act (FSA) of 1988, effective October 1990, which extended the previously state-optional AFDC-Unemployed Parent program to all states. This study clarifies what is meant by "two-parent" family in the federal legislation a...

We document a negative association between nonmarital childbearing and the subsequent likelihood of first marriage in the United States, controlling for a variety of potentially confounding influences. Nonmarital childbearing does not appear to be driven by low expectations of future marriage. Rather, it tends to be an unexpected and unwanted event, whose effects on a woman's subsequent likelih...

While the number of solved 3D protein structures continues to grow rapidly, the structural rules that distinguish protein-protein interactions between different structural families are still not clear. Here, we classify and analyse the secondary structural features and promiscuity of a comprehensive non-redundant set of domain family binding sites (DFBSs) and hetero domain-domain interactions (...

Workfare, reciprocal obligations, parental responsibility, and the need to balance opportunities with mandates have been prominent in the current lexicon of welfare reform, replacing the emphasis on entitlements and incentives familiar from an earlier era. This article discusses why the debate has shifted toward work strategies and summarizes what we know about the feasibility and success of th...

This research seeks to reevaluate the relationship between AFDC and fertility by focusing on births to women through the age of twenty-three using data from the National Longitudinal Survey of Youth (NLSY). Using discrete time hazard models, I examine the impact of AFDC on births directly associated with AFDC, on out-of-wedlock births, and on all births. I also examine the importance of AFDC on...

Introduction

Can economic incentives be used to affect marriage behavior and slow the growth of single-parent families? This paper provides new evidence on the effects of welfare benefit incentives on the marital decisions of poor women. Exogenous variation in welfare program parameters arises from a randomized experiment carried out in California. Whereas previous studies have measured women’s responses to...

Pfam is a database of protein families that currently contains 7973 entries (release 18.0). A recent development in Pfam has enabled the grouping of related families into clans. Pfam clans are described in detail, together with the new associated web pages. Improvements to the range of Pfam web tools and the first set of Pfam web services that allow programmatic access to the database and assoc...

A 10.5 kDa non-Pfam hypothetical protein, AF1514, from the hyperthermophilic archaeon Archeoglobus fulgidus has been overexpressed in Escherichia coli, purified and crystallized using the hanging-drop vapour-diffusion method. The crystals diffracted X-rays to 2.09 A resolution and a data set was collected at 100 K using Cu K alpha radiation from a rotating-anode X-ray source. The crystals belon...