Highly polarized cells such as photoreceptors require precise and efficient strategies for establishing and maintaining the proper subcellular distribution of proteins. The signals and molecular machinery that regulate trafficking and sorting of synaptic proteins within cone inner segments is mostly unknown. In this study, we show that the polyphosphoinositide phosphatase Synaptojanin 1 (SynJ1)...

BACKGROUND The genome of the halophilic archaeon Halobacterium salinarum NRC-1 encodes for homologs of MutS and MutL, which are key proteins of a DNA mismatch repair pathway conserved in Bacteria and Eukarya. Mismatch repair is essential for retaining the fidelity of genetic information and defects in this pathway result in the deleterious accumulation of mutations and in hereditary diseases in...

This study was conducted to evaluate the carcass yield, abdominal fat deposition and chemical compositions of thigh and breast muscles of male Arian broilers fed three different lysine levels of 1) high lysine (110% NRC), 2) standard level suggested by National Research Council (NRC) and 3) low lysine (90% NRC) based on two expression ways of amino acid contents of feedstuffs, as total amino ac...

Introduction: The Martian north polar residual cap (NRC) lies on top of the north polar layered deposits (NPLD). The NRC is about 1m thick and composed primarily of large-grained, dust-poor water ice [1]. The mass balance of the north polar cap is uncertain. Satellite imagery reveals small reversible changes in its extent on an interannual basis [2]. Images with a pixel scale of up to 0.25 m/pi...

Interannual variation of forage quantity and quality driven by precipitation events influence beef livestock production systems within the Southern and Northern Plains and Pacific West, which combined represent 60% (approximately 17.5 million) of the total beef cows in the United States. The beef cattle requirements published by the NRC are an important tool and excellent resource for both prof...

OBJECTIVE To examine the adoption of feeding recommendations among caregivers of children recuperating from malnutrition and assess the determinants of growth of children attending a nutrition rehabilitation centre (NRC) in Accra, Ghana. DESIGN Longitudinal study in which attendance and maternal programme participation were recorded daily and children's anthropometry and dietary intake were m...

The U.S. National Research Council (NRC) report on "Toxicity Testing in the 21st century" calls for a fundamental shift in the way that chemicals are tested for human health effects and evaluated in risk assessments. The new approach would move toward in vitro methods, typically using human cells in a high-throughput context. The in vitro methods would be designed to detect significant perturba...

Title of Document: RESISTANCE TO IONIZING RADIATION AND OXIDATIVE STRESS IN HALOBACTERIUM SALINARUM NRC-1 Courtney Kathryn Robinson, Master of Science, 2009 Directed By: Professor Jonathan Dinman, Department of Cell Biology and Molecular Genetics Oxidative stress results from environmental challenges that cause unchecked production of reactive oxygen species (ROS). We analyzed the cellular dama...

Human health is inextricably linked to the health of animals and the viability of ecosystems; this is a concept commonly known as One Health. Over the last 2 decades, the Institute of Medicine (IOM) and the National Research Council (NRC) have published consensus reports and workshop summaries addressing a variety of threats to animal, human, and ecosystem health. We reviewed a selection of the...

To determine if energy or phosphorus status would affect postpartum reproductive performance, we assigned primiparous heifers, six per group, to either high (135% NRC) or low (85% NRC) energy, and high (138% NRC) or low (98% NRC) phosphorus in a 2 x 2 factorial design. Treatments were continued from parturition through 84 days postpartum, after which standard diets were fed. The entire experime...