A key question in nuclear RNA surveillance is how target RNAs are recognized. To address this, we identified in vivo binding sites for nuclear RNA surveillance factors, Nrd1, Nab3 and the Trf4/5–Air1/2–Mtr4 polyadenylation (TRAMP) complex poly(A) polymerase Trf4, by UV crosslinking. Hit clusters were reproducibly found over known binding sites on small nucleolar RNAs (snoRNAs), pre-mRNAs and cr...

BACKGROUND Globally, rheumatic heart disease (RHD) remains an important cause of heart disease. In Australia it particularly affects older non-Indigenous Australians and Aboriginal Australians and/or Torres Strait Islander peoples. Factors associated with the choice of treatment for advanced RHD remain variable and poorly understood. METHODS The Australian and New Zealand Society of Cardiac a...

ErbB1 and ErbB2 receptors are well-characterized targets for anticancer drugs, but the clinical relevance of the related ErbB4 receptor is unknown. Here, we have assessed the clinical significance of the proteolytically cleavable ErbB4 isoforms in breast cancer patients and investigated their functions in vitro . The expression of transcripts encoding the cleavable ErbB4 isoforms associated wit...

BACKGROUND Gigantomastia is a rare condition characterized by excessive breast growth and can be physically and psychosocially disabling for the patient. Regarding management of gigantomastia, this study evaluates the outcomes of superomedial pedicle with vertical scar or wise pattern skin excision. METHODS A total of 425 patients who underwent reduction mammoplasty in our institution were re...

Modern software is playing an important role in teaching calculus to the students. Maple software is one of them. Maple software is a system that will be useful for mathematicians, teachers, engineers, researchers and scientists, who are faced with the design calculations, logical International Journal of Scientific & Engineering Research, Volume 7, Issue 3, March-2016 ISSN 2229-5518 1384 IJSER...

BACKGROUND Hypertension is a major cardiovascular risk factor, but knowledge about the real magnitude of the problem and its determinants is lacking. AIM To assess control of hypertension and evaluate medical resource use, in patients at high risk of cardiovascular disease. DESIGN Multicentric cross-sectional study. METHODS We collected data for 2205 adult patients from 36 centres, repres...