BACKGROUND Although knee pain is common in older persons and can cause ambulatory limitation, its impact on self-reliance has rarely been examined in Japan, particularly in a community setting. The aim of this 3-year cohort study was to investigate the association of knee pain with dependence in activities of daily living (ADL) and mortality in community-dwelling older Japanese adults. METHOD...

BACKGROUND It is well accepted that the gravid state is hypercoagulable and a significant cause of both maternal morbidity and mortality in the Western world. Although thrombin generation is reported to be increased in pregnant women, uncertainty exists on the pattern of thrombin generation change during this time. The aim of this study is to describe thrombin generation changes and D-dimer con...

We gave atropine intravenously to autonomically decentralized, open-chest, anesthetized dogs and stimulated the discrete intracardiac sympathetic nerve fibers to the sinoatrial (SA) (SAS stimulation) or atrioventricular (AV) (AVS stimulation) nodal region. A brief burst of neural stimuli was delivered during each cardiac cycle. SAS stimulation consistently decreased the atrial cycle length but ...

BackgroundThe evidence for temperature control comatose survivors of cardiac arrest is inconclusive. Controversy exists as to whether the effects hypothermia differ per circumstances or patient characteristics.MethodsAn individual data meta-analysis Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest (TTM) and Hypothermia Normothermia Out-of-Hospital (TTM2) trials was condu...

1391 nutritional health, and emerging research and practices regarding nutrition, diet, and oral medicine. Although the chapter “Complementary and Alternative Medical Practices” include some therapies not recognized as the standard of care by the American Dental Association, it is well written and informative. Section four, “Select Diseases and Conditions with Known Nutrition and Oral Health Co...

BACKGROUND Chest-x-ray is routinely used in the diagnosis of smear negative tuberculosis (TB). This study assesses the incremental cost per true positive test of a point-of-care digital chest-x-ray, in the diagnosis of pulmonary mycobacterial infections among HIV patients with presumed tuberculosis undetected by smear microscopy. METHODS Consecutive patients with clinical suspicion of pulmona...