There are several potential mechanisms by which HDLs protect against the development of vascular disease. One relates to the unique ability of these lipoproteins to remove cholesterol from the arterial wall. Another is the ability of HDL to prevent and eventually correct endothelial dysfunction, a key variable in the pathogenesis of atherosclerosis and its complications. HDLs help maintain endo...

This document specifies an extension of the Routing Information Protocol (RIP), as defined in [1,2], to expand the amount of useful information carried in RIP messages and to add a measure of security. This memo obsoletes RFC 1388, which specifies an update to the "Routing Information Protocol" STD 34, RFC 1058. The RIP-2 protocol analysis is documented in RFC 1721 [4]. The RIP-2 applicability ...

A novel generation of retroviral gene-trap vectors has been developed with the ability to induce conditional mutations in most genes expressed in mouse embryonic stem (ES) cells. The vectors rely on directional site-specific recombination systems, which can repair and re-induce the gene-trap mutations when activated in succession. After the gene-trap insertions are passaged into mice, this syst...

The aim of the present study was to compare the effects of selective phosphodiesterase (PDE) 3, 4 and 5 inhibitors on antigen-induced airway hyperresponsiveness in sensitized guinea-pigs. When the sensitized guinea-pigs were orally pre-treated with the selective PDE4 inhibitor, Ro 20-1724 (30 mg/kg), and studied 48h after OA, a significant reduction (P<0.01) of the leftward shift of the dose-re...

1. Caravaca F, Lopez-Minguez JR, Arrobas M et al. Haemodynamic changes induced by the correction of anaemia by erythropoietin: role of antiplatelet therapy. Nephrol Dial Transplant 1995; 10: 1720-1724 2. Anastassiades E, Howarth D, Howarth J et al. Influence of blood volume on the blood pressure of predialysis and peritoneal dialysis patients treated with erythropoietin. Nephrol Dial Transplant...

[1] The interdecadal variability of summer precipitation in Beijing from 1724 to 2005 is analyzed using a filter, keeping the true trends at time series ends. A probability distribution, Pearson type III, was applied to the summer precipitation series to estimate the probability of anomalous rainfall. This study includes the correlation between the interdecadal variations of the summer precipit...

In 1995 a group of 1724 randomly selected Minnesota taxpayers was informed by letter that the returns they were about to file would be ‘closely examined’. Compared to a control group that did not receive this letter, low and middle-income taxpayers in the treatment group on average increased tax payments compared to the previous year, which we interpret as indicating the presence of noncomplian...

The German philosopher Immanuel Kant (1724–1804) defined living organisms as objects with an intrinsic purpose, which are self-organized in such a way that every part is a function of the whole and the whole is a function of every part, and in which “nothing is for nothing”. Kant already anticipated the tension between agency and structure, and between forward and backward causation. He also pe...

The effect of calcitonin gene-related peptide (CGRP) on the cyclic nucleotide level in isolated mouse diaphragm was investigated. CGRP at concentrations of up to 1 microM caused dose-dependent increases in cyclic AMP levels but had no effect on cyclic GMP levels. At 1 microM, CGRP increased cyclic AMP levels by about 2.7-fold. Moreover, in the presence of phosphodiesterase inhibitor (Ro 20-1724...