RATIONALE Large-conductance calcium-activated potassium channels (BK) are composed of pore-forming BKα and auxiliary β1 subunits in arterial smooth muscle cells (myocytes). Vasoconstrictors, including endothelin-1 (ET-1), inhibit myocyte BK channels, leading to contraction, but mechanisms involved are unclear. Recent evidence indicates that BKα is primarily plasma membrane localized, whereas th...

clude some 500 species and are widespread in temperate and tropical climates. Phyllanthus species have attracted the attention of researchers for their hepatoprotective properties; an aqueous extract of Phyllanthus amarus was demonstrated to exert antihepatitis B virus effects to varying degrees. In 2003, various constituents isolated from Phyllanthus species were screened for anti-human hepati...

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Introduction:Targeted radionuclide therapy (TRT) has been demonstrated to be an effective therapeutic tool in patients with disseminated bone metastasis. TRT is generally performed with a single radionuclide. In this study we investigated the feasibility of combined TRT with a high-energy beta emitter (153Sm) and a low energy beta emitter (177Lu) in wistar...